Hemp Seed Awareness

Last updated: June 10, 2024
Sponsor: University Hospital, Angers
Overall Status: Active - Recruiting

Phase

N/A

Condition

Allergy

Treatment

hemp prick-test

Clinical Study ID

NCT04841954
49RC21_0048
  • Ages > 18
  • All Genders

Study Summary

Hemp is a plant of the Cannabaceae family. Cannabis sativa, derived from female flowers, is the first illicit substance used by adolescents and is a major public health problem. Its psycho-active effects come from tetrahydrocannabinol (THC).

Unlike recreational cannabis, industrial hemp derived from cannabis sativa has a high level of cannabidiol (CBD) but a negligible level of tetrahydrocannabinol. Its seeds are now consumed in various forms and generate increasing interest. Seeds have many nutritional benefits.

It seems important to take an interest in hemp, given the recent expansion of medical cannabis and the increasing use of cannabis for recreational purposes. It is incriminated in various allergies (contact dermatitis, asthma, rhinoconjunctivitis) but also in the occurrence of anaphylaxis to certain foods by cross-allergy in atopic subjects, in association with an Lipid-Transfer Proteins (LTP protein), present in the flower of Cannabis sativa.

Unlike the allergy to recreational cannabis, the allergenicity of hemp seeds is little studied.

Hemp seed can cause severe anaphylactic reactions. In all reported cases, the prick-tests were positive for the seeds. Often, patients had never been in contact with hemp seeds but had already been exposed to cannabis by respiratory or manual routes.

The investigators hypothesize that sensitization by the skin or respiratory route (cannabis smokers, passive exposure to cannabis, workers exposed to hemp, etc.) could lead to the development of a food allergy to hemp seed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Major patient

  • Patient referred to the Allergology Unit of the Hospital of Angers, in consultationor in Hospitalization - for conducting prick-tests

  • Patient affiliated or beneficiary of a social security scheme

  • Patient with informed consent

Exclusion

Exclusion Criteria:

  • Pregnant women, parturients

  • Persons deprived of liberty by administrative or judicial decision

  • Persons receiving psychiatric care under duress

  • Adults under legal protection measure

  • People out of state to express consent

  • people not able to understand French language

  • Patients whose skin reactivity prevents interpretation of tests (patients who cannotinterrupt anti-histamines or have severe eczema)

Study Design

Total Participants: 600
Treatment Group(s): 1
Primary Treatment: hemp prick-test
Phase:
Study Start date:
June 01, 2021
Estimated Completion Date:
May 31, 2025

Connect with a study center

  • MORISSET Martine

    Angers,
    France

    Active - Recruiting

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