Double Filtration Plasmapheresis Combined With Chemotherapy

Last updated: July 12, 2023
Sponsor: Fuling Zhou
Overall Status: Active - Recruiting

Phase

1

Condition

Multiple Myeloma

Lymphoproliferative Disorders

Bone Diseases

Treatment

DFPP combined with chemotherapy

Clinical Study ID

NCT04836871
01
  • Ages > 18
  • All Genders

Study Summary

Evaluation of double filtration plasmapheresis combined with chemotherapy for the treatment of abnormalities of M protein or renal function due to the multiple myeloma.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Multiple myeloma patients who are diagnosed by bone marrow morphology and immunology
  • Patients with stable condition after conventional treatment
  • Patients with renal insufficiency or abnormal M protein
  • Patients over 18 years of age
  • Liver function: blood bilirubin ≤ 35μmol/L, enzymes aspartate transaminase (AST)/akaalanine aminotransferase (ALT) is less than 2 times the upper limit of normal
  • Normal heart function
  • Physical condition score 0-2 level (ECOG score)
  • Obtain an informed consent form signed by the patient or family member

Exclusion

Exclusion Criteria:

  • Allergies or obvious contraindications to any of the drugs involved in the plan
  • Severe heart disease, including myocardial infarction and cardiac insufficiency.
  • Suffering from other organ malignancies
  • Active tuberculosis patients and HIV-positive patients
  • At the same time suffering from other blood system diseases
  • Pregnant or lactating women
  • Able to understand or follow the research plan
  • Past history of intolerance or allergy to similar drugs
  • Patients under 18 years of age
  • Participating in other clinical researchers at the same time
  • There are any other circumstances that hinder the progress of the research

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: DFPP combined with chemotherapy
Phase: 1
Study Start date:
May 15, 2021
Estimated Completion Date:
October 31, 2024

Connect with a study center

  • Zhongnan Hospital of Wuhan University

    Wuhan, Hubei 430071
    China

    Active - Recruiting

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