Tenting Screws in Combination With Platelet Concentrate for Vertical Alveolar Ridge Augmentation

Last updated: September 27, 2021
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

N/A

Clinical Study ID

NCT04835532
2021-0050
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Alveolar bone resorption often occurs after tooth extraction. At present, guided bone regeneration technique is widely used in clinic since it leads to less trauma and less complications. Tenting screw technology, basic on the classical GBR, implants screws into the surgical area to prevent the barrier membrane from collapsing. Moreover, advanced platelet rich fibrin and injectable platelet-rich fibrin are used to provide the osteogenic function. The investigators intend to increase vertical alveolar bone augmentation by combining tenting screws and A-PRF, I-PRF.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. 18-80 years old;
  2. single tooth in the maxillary posterior area cannot be retained (third degreeloosening / alveolar bone resorption to the periapical area), implantation is neededafter extraction, and CBCT shows vertical bone defect ≥ 3mm;
  3. 4 weeks after extraction or missing teeth within 3-5 weeks;
  4. adjacent teeth exist and loosening is less than Ⅰ degree;
  5. periodontal disease in inactive stage, whole mouth bleeding index (FMBS) is less than 20%;
  6. thick gingival biological type.
  7. CBCT shows that the bone of the edentulous site meets the requirements of tent screwimplantation (bone height ≥ 3mm and bone mineral density is sufficient);
  8. the patients and their families have informed consent and signed the informed consentform.

Exclusion

Exclusion Criteria:

  1. pregnant and lactating women;
  2. smoking (> 10 cigarettes per day) and alcoholism;
  3. taking anticoagulants within 3 months before operation;
  4. suffering from autoimmune diseases, diabetes, liver disease, blood system diseases andinfectious diseases;
  5. patients taking any drugs that affect platelet function or whose platelet count isless than 200000/mm3 3 months before blood collection;
  6. patients who have been treated with bisphosphate / steroids for a long time;
  7. have received alveolar ridge bone augmentation surgery;
  8. previous history of radiotherapy in the head and neck;
  9. acute inflammation in edentulous sites;
  10. inability to maintain good oral hygiene or follow-up visits as required.

Study Design

Total Participants: 69
Study Start date:
August 10, 2021
Estimated Completion Date:
March 01, 2024

Study Description

Alveolar bone resorption often occurs after tooth extraction. At present, guided bone regeneration technique is widely used in clinic since it leads to less trauma and less complications. Tenting screw technology, basic on the classical GBR, implants screws into the surgical area to prevent the barrier membrane from collapsing. Moreover, advanced platelet rich fibrin and injectable platelet-rich fibrin are used to provide the osteogenic function. The investigators intend to increase vertical alveolar bone augmentation by combining tenting screws and A-PRF, I-PRF.

Connect with a study center

  • 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

    Hangzhou, Zhejiang 310000
    China

    Active - Recruiting

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