ASL in Brain Metastasis MRI Following Gamma Knife Treatment

Last updated: June 7, 2024
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasm Metastasis

Brain Metastases

Treatment

MRI perfusion sequence

Clinical Study ID

NCT04833335
APHP190736
  • Ages > 18
  • All Genders

Study Summary

Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment.

The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Brain metastasis from histologically proven tumor

  • GK treatment within 4 month prior to the inclusion

  • Lesions suspected of progression/ radionecrosis : i.e.≥ 25% of the size progression

  • Lesion size: gadolinium enhanced part of the tumour ≥1 cm

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Medical history of primitive brain tumour

  • MRI incompatibility/ medical history of contrast agent allergy

  • Claustrophobia

  • Patient unable to consent

  • Epilepsia/recent stroke

  • Patients participating in other studies

  • Patients without health care insurance

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: MRI perfusion sequence
Phase:
Study Start date:
January 24, 2023
Estimated Completion Date:
January 24, 2026

Study Description

The metastasis progression versus radionecrosis following GK treatment can sometimes be difficult to distinguish. 60 patients will be included in this prospective, monocentric study. 3 MRI (baseline, 1month and 6 month follow-ups) will be performed. Two neuroradiologists will blindly analyse the MRIs comparing ASL sensibility and specificity to the standard morphological evaluation and T2 perfusion.

Connect with a study center

  • Service de neuroradiologie, hôpital Pitié Salpêtrière

    Paris, 75013
    France

    Active - Recruiting

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