A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder

Inclusion Criteria:

1. Recurrent MDD diagnosis with a current episode duration of at least 8 weeks and nomore than 24 months.
2. HAM-D17 total score of ≥23 at Screening and Baseline.
3. Body mass index (BMI) between 18 and 38 kg/m2 (inclusive).

Exclusion Criteria:

1. Lifetime history of seizures, including febrile seizures.
2. Neurodegenerative disorder (eg, Alzheimer's disease, Parkinson's disease, multiplesclerosis, or Huntington's disease).
3. Lifetime history of bipolar disorder, a psychotic disorder (eg, schizophrenia orschizoaffective disorder), or obsessive compulsive disorder or a history of apsychotic mood episode in last 2 years.
4. Any current psychiatric disorder (other than MDD).
5. Lifetime history of treatment resistant depression.
6. Received electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS) within thelast year or transcranial magnetic stimulation (TMS) within the last 6 months prior toScreening.
7. Daily consumption of more than 2 standard alcohol-containing beverages for males ormore than 1 standard alcohol-containing beverages for females.