Safety and Efficacy of Low-intensity Shockwave Therapy for Peyronie's Disease

Inclusion Criteria:

• ≥18 years old male,

• Untreated Peyronie's disease (excepted oral therapy) (wash out: at least 1 month),

• Single axis penile curvature in erection at 20 - 90 degrees at baseline,

• Dorsal or lateral penile plaque,

• Able and willing to perform ESWT self-treatment under supervision,

• Able to understand and complete patient questionnaires,

• Having sign an informed consent form prior to any study specific procedure,

• Being covered by a national health insurance

Exclusion Criteria:

• Congenital penile deformity,

• Hourglass deformity,

• Circumferential plaque,

• Septal or ventral plaque,

• Plaque that cannot be palpated during clinical examination,

• Previous intralesional injection for Peyronie's Disease,

• Severe erectile dysfunction (EHS < 3),

• Current penile, malignancy,

• Previous penile surgery except for circumcision or condyloma removal,

• Previous pelvic radiation therapy,

• Anti-coagulant medication, except acetylsalicylic acid up to 100mg daily,

• Previous low-intensity focused shockwave therapy on penis,

• Any other condition that would prevent the patient from completing the study, asjudged by the principal investigator,

• Being deprived of liberty or under guardianship.