Persona Ti-Nidium Post-Market Clinical Follow-up

Inclusion Criteria:

1. Patient is of legal age and skeletally mature

2. Patient is willing and able to provide written Informed Consent by signing anddating the IRB-approved Informed Consent document

3. Patient is willing and able to complete scheduled follow-up evaluations as definedin the study protocol

4. Patient qualifies for total knee arthroplasty based upon physical exam and medicalhistory, and meets the approved indications for use of the Persona Ti-Nidium KneeSystem and Vivacit-E polyethylene articulating surface

5. Independent of study participation, patient is a candidate for the commerciallyavailable Persona Ti-Nidium Knee and Vivacit-E polyethylene articulating surface,implanted in accordance with product labeling

Study Device Inclusion Criteria:

The Persona Ti-Nidium Total Knee is intended for patients with severe pain and disability due to the following:

1. Rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis.

2. Collagen disorders, and/or avascular necrosis of the femoral condyle.

3. Post-traumatic loss of joint configuration, particularly when there ispatellofemoral erosion, dysfunction or prior patellectomy.

4. Moderate valgus, varus, or flexion deformities.

Exclusion Criteria:

1. Patient is unwilling to sign the Informed Consent

2. Patient is currently participating in any other surgical intervention or painmanagement study

3. Patient is pregnant or considered a member of a protected (vulnerable) populationwhose inclusion in the study is inappropriate (e.g. prisoner, mentally incompetent)

4. Patient has a mental or neurologic condition who is unwilling or incapable offollowing postoperative care instructions

5. Patient has a condition which would, in the judgement of the Investigator, place thepatient at undue risk or interfere with the conduct of the study

6. Patient is institutionalized or is a known drug abuser, a known alcoholic or cannotunderstand the requirements of study participation

Study Device Exclusion Criteria

1. Previous history of infection in the affected joint and/or other local/systematicinfection that may affect the prosthetic joint

2. Insufficient bone stock on femoral or tibial surfaces

3. Skeletal immaturity

4. Neuropathic arthropathy

5. Osteoporosis or any loss of musculature or neuromuscular disease that compromisesthe affected limb

6. A stable, painless arthrodesis in a satisfactory functional position

7. Severe instability secondary to the absence of collateral ligament integrity

8. Rheumatoid arthritis (RA) accompanied by an ulcer of the skin or a history ofrecurrent breakdown of the skin

9. The kinematic alignment surgical technique is contraindicated for patients withgreater than 5° valgus deformity with medial collateral ligament (MCL) insufficiency