Young Houston Emergency Opioid Engagement System

Last updated: December 5, 2024
Sponsor: The University of Texas Health Science Center, Houston
Overall Status: Active - Recruiting

Phase

4

Condition

Stimulant Use Disorder

Addictions

Opioid Use Disorder

Treatment

Referral to Medication Management

Buprenorphine, Naloxone Drug Combination

Individual Counseling

Clinical Study ID

NCT04811014
HSC-MS-20-1376
  • Ages 13-17
  • All Genders

Study Summary

The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare differences in engagement and retention in treatment for individuals with opioid use disorder. The investigators also intend to understand the prevalence of opioid overdoses and OUD among youth in Houston.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • In otherwise good health based on physician assessment and medical history

  • Drug screen positive for opioids

  • Patients express a willingness to stop opioid use

  • Meet Diagnostic and Statistical Manual of Mental Disorders - Text Revision (DSM-IV-TR) criteria for opioid dependence

  • Patients must be able to speak English

  • Be agreeable to and capable of signing the informed consent and assent (parent orguardian must consent, minor must assent)

Exclusion

Exclusion Criteria:

  • Non-English-speaking patients

  • Have a known sensitivity to buprenorphine or naloxone

  • Be physiologically dependent on alcohol, benzodiazepines, or other drugs of abusethat require immediate medical attention. Other substance use diagnoses are notexclusionary.

  • Have a medical condition that would, in the opinion of the study physician, makeparticipation medically hazardous, including unstable cardiovascular disease,neurological deficits, trauma, acute hepatitis, stroke, and liver or renal disease)

  • Be acutely psychotic, severely depressed, and in need of inpatient treatment, or isan immediate suicide risk

  • Be a nursing or pregnant female

Study Design

Total Participants: 15
Treatment Group(s): 6
Primary Treatment: Referral to Medication Management
Phase: 4
Study Start date:
April 19, 2021
Estimated Completion Date:
August 31, 2027

Study Description

The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a non-randomized cohort study based at the University of Texas Health Science Center of Houston. This study recruits participants through three avenues: assertive community outreach with a peer coach and paramedic following and opioid overdose, community referrals, and emergency department referrals. The study explores the effect of the combination of assertive outreach, same-day induction into medication for opioid use disorder, ongoing maintenance treatment, behavioral counseling, peer recovery support, and paramedic follow-up on patient outcomes. The primary outcome is engagement and retention in outpatient treatment. Secondary outcomes include quality of life assessment as well as subsequent relapses and overdoses. The hypothesis is that patients with earlier induction into MOUD treatment who receive routine follow-up, are more likely to engage and remain in treatment long-term.

Connect with a study center

  • The University of Texas Health Science Center at Houston

    Houston, Texas 77030
    United States

    Active - Recruiting

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