Early Nutritional Intervention in NPC Patients Undergoing Concurrent Chemoradiotherapy

Inclusion Criteria:

• Pathologically confirmed nasopharyngeal carcinoma (NPC).
• The clinical stage of NPC is T1-4 N1-3 M0 (AJCC 7th edition).
• Planned to receive concurrent chemoradiotherapy with intensity-modulated radiationtherapy (IMRT).
• Age ≥ 18 years and < 75 years.
• Performance status (PS) score 0-1.
• NRS2002<3 .
• Blood regular test should be satisfied the following conditions: white blood cellcount ≥3.5×109/L， Neutrophil count ≥1.5×109/L，platelet count ≥100×109/L，hemoglobin ≥10g/L
• Liver and kidney functions test should be satisfied the following conditions:aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) < 2.5 times theupper limit of normal value, bilirubin < 1.2 times the upper limit of normal value,creatinine < 1.2 times the upper limit of normal value, and alkaline phosphatase < 5times the upper limit of normal value.
• Could complete required oral nutrition, questionnaire survey and follow-up.
• Signed informed consent voluntarily.

Exclusion Criteria:

• Had a history of head and neck radiotherapy.
• Known allergic reaction to any component of ONS, or severe allergic constitution.
• With any unstable systemic disease (such as uncontrolled infectious diseases,uncontrolled hypertension, uncontrolled metabolic diseases and so on).
• Serious cardiovascular diseases in 6 months (such as Congestive heart failure andmyocardial infarction).
• Pregnancy and lactation.
• Other conditions that the investigators consider as inappropriate for enrolling intothis study.
• Has a history of malignant tumors in 5 years, except for tumors that have been curedonly by surgery and with a disease free survival for five years, cured basal cellcarcinoma of skin and cured carcinoma in situ of the cervix.