Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis

Inclusion Criteria:

1. For adult subjects: Participants legally competent to sign and give informedconsent. For pediatric and adolescent subjects: Informed consent of parent(s) orlegal guardian, and, if age appropriate, assent by the subjects, as required bylocal laws.

2. Males and females, ages 2 years and older. (Only subjects 18 years and older will beenrolled at sites located in the province of Québec in Canada.)

3. Subjects with atopic dermatitis who met eligibility criteria for and successfullycompleted one of three preceding studies through Week 4, and are able and eligibleto enroll into this long-term safety study on the Week 4 visit of the precedingstudy.

4. Females of childbearing potential (FOCBP) must have a negative urine pregnancy testat all study visits. In addition, sexually active FOCBP must agree to use at leastone form of a highly effective or barrier method of contraception throughout thetrial.

5. Females of non-childbearing potential should either be pre-menarchal, orpost-menopausal with spontaneous amenorrhea for at least 12 months (post-menopausalstatus would have been confirmed with FSH testing in the preceding study) or haveundergone surgical sterilization (permanent sterilization methods includehysterectomy, bilateral oophorectomy, or bilateral salpingectomy).

6. Subjects and parent(s)/legal guardian(s) are considered reliable and capable ofadhering to the Protocol and visit schedule, according to the judgment of theInvestigator.

Exclusion Criteria:

1. Subjects who experienced a treatment-related AE or a serious AE (SAE) that precludedfurther treatment with ARQ-151 cream in the preceding study.

2. Subjects that use any Excluded Medications and Treatments.

3. Subjects with skin conditions other than AD that would interfere with evaluations ofthe effect of the study medication on AD, as determined by the Investigator.Subjects with any condition on the treatment area which, in the opinion of theInvestigator, could confound efficacy measurements.

4. Subjects with known genetic dermatological conditions that overlap with AD.

5. Females who are pregnant, wishing to become pregnant during the study, or arebreast-feeding.

6. Subjects and parent(s)/legal guardian(s) who are unable to communicate, read orunderstand the local language(s), or who display another condition, which in theInvestigator's opinion, makes them unsuitable for clinical study participation.

7. Subjects who are family members of the clinical study site, clinical study staff, orsponsor, or family members of enrolled subjects (subjects enrolled in other studiesof ARQ-151 cream) living in the same house.