Study of the Difference Between Anorexia Nervosa with a History of Psychological Trauma and Classical Anorexia Nervosa on the Neurocognitive and Neurophysiological Factors

Last updated: January 8, 2025
Sponsor: University Hospital, Montpellier
Overall Status: Terminated

Phase

N/A

Condition

Anorexia

Vomiting

Treatment

Exposition Test

Clinical Study ID

NCT04804358
RECHMPL20_0186
  • Ages 18-65
  • Female

Study Summary

Recent studies suggest that patients with an history of trauma may represent a specific subtype of anorexia nervosa (AM) underlined by specific neurobiological and psychopathological mechanisms. Thus, AM-T subjects would manifest cognitive (specific difficulties in executive functions), emotional (emotional disruption, impulsivity, etc.) and neurobiological (secretion of kynurenine and neurokinins in the face of stress) caracteristics different from those of AM subjects.

Eligibility Criteria

Inclusion

Inclusion criteria common to the 2 groups AM-T and AM-C :

  • Women Patient

  • Present a diagnosis of anorexia nervosa according to the DSM-5 criteria

  • Between 18 and 65 years old

  • Present a BMI> 14

  • Do not present a sight problem or be corrected appropriately by wearing glasses orcontact lenses.

  • Be affiliated to a social security scheme, or beneficiary of such a scheme

  • Be able to understand the nature, purpose and methodology of the study

Inclusion criteria specific to patients in the AM-T group:

  • To have answered at least one of the grayed out items of the LEC-5, that is to sayto have answered "it happened to me" to at least one of the items 1 to 13 or to item 16 "and / or having answered" I witnessed it "to at least one of items 14 and 15.

Inclusion criteria specific to patients in the AM-C group:

  • Not having answered "it happened to me" or "I witnessed it" to one of the items ofLEC-5

Exclusion

Exclusion Criteria:

  • Present a severe unstable mental pathology in the opinion of the investigator

  • Present active suicidal ideation

  • Have consumed psychoactive substances in the last 24 hours before the assessment

  • Present a severe major depressive episode incompatible with the assessment, in theopinion of the investigator.

  • Present in the opinion of the investigator an unstable somatic state (eg severemetabolic disorder making it impossible or likely to impair the reliability ofneuropsychological and cardiac evaluations).

  • Take a drug treatment acting on the cardiovascular system

  • Refusal of the patient

  • Be protected by law (tutorship or curatorship).

  • To be deprived of liberty by administrative decision.

Study Design

Total Participants: 4
Treatment Group(s): 1
Primary Treatment: Exposition Test
Phase:
Study Start date:
September 17, 2021
Estimated Completion Date:
October 29, 2021

Study Description

We will recruit a total of 100 patients with a diagnosis of anorexia nervosa in the university hospital of Montpellier : 50 patients with an history of psychological trauma and 50 patients without any history of psychological trauma

Participation consists of a half-day visit. Patients will perform clinical and neuropsychological assessments and an exposition test. During this test, participants will be exposed, for 7 minutes, to neutral, positive or negative emotional photos. Heart rate variability will be determined through a Biopac MP160 before, during and after this event. Saliva samples to measure kynurenin, tryptophan, substance P and neurokinin-1 will be collected before and directly after the test.

Connect with a study center

  • University Hospital, Montpellier

    Montpellier,
    France

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.