Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Key Inclusion Criteria:

• Documented diagnosis of non-small cell lung, pancreatic, colorectal, prostate, breastor ovarian cancer which, in the treating oncologist's assessment, is consideredadvanced.
• Anorexia as defined by a score of ≤5 in the Cancer-Related Cachexia Symptom AssessmentAppetite 7-day recall scale
• Meets any of the following criteria at Randomization:
• Not currently receiving antineoplastic therapy
• On standard of care systemic antineoplastic therapy or treatment without curativeintent
• Signed informed consent.

Key Exclusion Criteria:

• Receiving tube feedings or parenteral nutrition at the time of Screening orRandomization.
• Current active reversible causes of decreased food intake.
• Current, severe gastrointestinal disease
• Participants with known symptomatic brain metastases requiring steroids.
• Active uncontrolled bacterial, fungal, or viral infection, including HBV, HCV, HIV orparticipants with known AIDS-related illness
• inadequate renal or liver function.
• Women who are pregnant or breast-feeding