Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

Last updated: May 19, 2025
Sponsor: Neurobehavioral Systems, Inc.
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mental Disability

Dementia

Memory Loss

Treatment

California Cognitive Assessment Battery

Clinical Study ID

NCT04800588
4R44AG062076
  • Ages 18-89
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive decline.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must be able to use computer mouse and touch screen

  • Must speak English as a primary language

  • Must speak Spanish as a primary language (for Latino participants completing ourSpanish translation)

Exclusion

Exclusion Criteria:

  • History of psychiatric disorder

  • History of stroke or transient ischemic attack

  • History of substance abuse

  • History of medical or sensory disorders that are incompatible with effective testing

  • History of traumatic brain injury with hospitalization and extended loss ofconsciousness

  • History of epilepsy

  • History of depression or anxiety

Study Design

Total Participants: 2000
Treatment Group(s): 1
Primary Treatment: California Cognitive Assessment Battery
Phase:
Study Start date:
May 05, 2021
Estimated Completion Date:
March 31, 2027

Study Description

In Group A, the investigators will evaluate the performance of healthy older participants (N = 300, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. The goal is to characterize changes in performance to aging and task experience in a group of older subjects.

In Group B, the investigators will compare the performance of normal participants (N = 100, age range 18 to 89) on computerized and manually administered cognitive tasks.

In Group C, the investigators will gather normative data from participants across the age range (N = 100, ages 18 to 89) for three days at enrollment, to better characterize test-retest reliability scores on Day 1 tasks.

In Group D, the investigators will evaluate the performance of healthy older participants (N = 1200, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. In the aim of better understanding health disparities in cognitive testing, this group will be divided into four cohorts: 300 African American participants; 300 Asian American participants; 300 Latino English-speaking participants; and 300 Latino Spanish-speaking participants, who will complete a Spanish translation of our computerized cognitive tests.

Connect with a study center

  • Neurobehavioral Systems, Inc.

    Berkeley, California 94704
    United States

    Active - Recruiting

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