Pharmacodynamic Effects of Cangrelor in ACS or CCS Patients Undergoing PCI (POMPEII Registry)

Last updated: August 4, 2025
Sponsor: Federico II University
Overall Status: Completed

Phase

N/A

Condition

Open Heart Surgery

Treatment

Cangrelor

Clinical Study ID

NCT04790032
POMPEII Registry
  • Ages > 18
  • All Genders

Study Summary

This prospective registry was designed to carefully investigate the pharmacodynamic (PD) effects of cangrelor in all patients undergoing percutaneous coronary intervention (PCI).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All adult patients undergoing PCI and receiving cangrelor administration will beeligible for inclusion in the study.

Exclusion

Exclusion Criteria:

  • only those not providing consent to blood/data collection will be excluded.

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Cangrelor
Phase:
Study Start date:
March 16, 2021
Estimated Completion Date:
July 01, 2024

Study Description

There is huge interest in achieving fast and immediate antiplatelet effect at the time of PCI, particularly in acute myocardial infarction and Cangrelor is an intravenous antagonist of the P2Y12 receptor characterized by rapid, potent, predictable, and reversible platelet inhibition. However, there are limited pharmacodynamic data exploring the effects of this drug in the various clinical settings at the approved dosages and with current gold standard methods for testing platelet reactivity. More importantly, there are no data on rates and predictors of high residual platelet reactivity (HRPR) in patients treated with cangrelor. Therefore the present study aims at building up a large prospective registry of pharmacodynamic data obtained by light transmittance aggregometry (LTA), multiplate analysis and verifynow system in patients undergoing PCI and receiving cangrelor.

This study is designed as a single-center prospective registry. Investigators at University Hospital of Naples Federico II will enroll patients, collect blood samples, perform platelet function tests and collect clinical and demographic information.

Connect with a study center

  • University Federico II of Naples

    Napoli, 80131
    Italy

    Site Not Available

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