COVID-19 Infection and Epithelial Cell Markers

Last updated: March 5, 2021
Sponsor: McMaster University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Asthma

Treatment

N/A

Clinical Study ID

NCT04787588
11033-T
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 years and above;
  • Able to give informed consent;
  • Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g.RT-PCR) and with a positive result and clinical features in keeping with COVID-19illness. The control group will be patients with a negative RT-PCR COVID-19 test andwithout any clinical features to suggest COVID-19 illness. In addition, the controlgroup should have NO known or current features of respiratory infection, COPD, asthma,interstitial lung disease, other respiratory inflammatory conditions or lung cancer.
  • Able to provide a breath sample (as based on clinical judgement).

Exclusion

Exclusion Criteria:

  • none

Study Design

Total Participants: 235
Study Start date:
February 14, 2021
Estimated Completion Date:
February 01, 2022

Study Description

The study aim is to determine the relationship between COVID-19 infection and epithelial cell expression of TSLP. Two cohorts will be used. Cohort One will include 100 hospitalized patients with Covid-19, and 100 hospitalized patients without Covid-19. Cohort 2 will include mild/moderate asthmatics and healthy controls with bio-banked biopsy material used from donors who have previously consented for samples to be used for future research.

Connect with a study center

  • McMaster Cardio-Respiratory Research Lab

    Hamilton, Ontario L8N 3Z5
    Canada

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.