Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

Inclusion Criteria:

• The subject's treating clinician has decided that REAL INTELLIGENCE™ CORI™ and acompatible Smith+Nephew Knee Implant System is the best treatment for the subject'sunicondylar knee arthroplasty (UKA) or total knee arthroplasty (TKA) and the subjecthas agreed to the treatment.

• Subject requires a cemented UKA or TKA as a primary indication that meets eithercriterion A or B.

• A. Subject requires a cemented UKA as a primary indication due to any of thefollowing conditions:

1. Non-inflammatory degenerative joint disease, including osteoarthritis
2. Avascular necrosis
3. Requires correction of functional deformity
4. Requires treatment of fractures that were unmanageable using othertechniques

• B. Subject requires a cemented TKA as a primary indication due to any of thefollowing condition:

1. Degenerative joint disease, including osteoarthritis
2. Rheumatoid arthritis
3. Avascular necrosis
4. Requires correction of functional deformity
5. Requires treatment of fractures that were unmanageable using othertechniques

• Subject is of legal age to consent and considered skeletally mature (≥ 18 years ofage at the time of surgery)

• Subject agrees to consent to and to follow the study visit schedule (as defined inthe study protocol and informed consent form), by signing the Ethical Committee (EC)or Institutional Review Board (IRB) approved informed consent form.

• Subject plans to be available through one (1) year postoperative follow-up.

• Routine radiographic assessment is possible.

• Subject able to follow instructions and deemed capable of completing all studyquestionnaires.

Exclusion Criteria:

• Subject receives a CORI Robotics UKA or TKA on the index joint as a revision for apreviously failed surgery, or need for complex implants, or any other implant than astandard UKA or TKA (e.g. stems, augments, or custom made devices).

• Subject has been diagnosed with post-traumatic arthritis

• Subject receives bilateral UKA or TKA

• Subject does not understand the language used in the Informed Consent Form.

• Subject does not meet the indication or is contraindicated for UKA or TKA accordingto specific Smith+Nephew knee system's Instructions For Use (IFU).

• Subject has active infection or sepsis (treated or untreated).

• Subject is morbidly obese with a body mass index (BMI) greater than 40.

• Subject is pregnant or breast feeding at the time of surgery.

• Subject, in the opinion of the Investigator, has advanced osteoarthritis or jointdisease at the time of surgery and was better suited for an alternate procedure.

• Subject has a condition(s) that may interfere with the TKA or UKA survival oroutcome (i.e., Paget's or Charcot's disease, vascular insufficiency, muscularatrophy, uncontrolled diabetes, moderate to severe renal insufficiency orneuromuscular disease, or an active, local infection).

• Subject in the opinion of the Investigator, has an emotional or neurologicalcondition that would pre-empt their ability or willingness to participate in thestudy including mental illness, mental retardation, drug or alcohol abuse.

• Subject, in the opinion of the Investigator, has a neuromuscular disorder thatprohibited control of the index joint.

• Subject is a prisoner or meets the definition of a Vulnerable Subject per ISO 14155Section 3.55.