Comprehensive Swallowing Rehabilitation in Patients With MSA

Last updated: May 19, 2025
Sponsor: Seoul National University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Multiple System Atrophy

Treatment

Comprehensive swallowing rehabilitation

Swallowing education

Clinical Study ID

NCT04782284
MSA-swrehab-RCT
  • Ages > 19
  • All Genders

Study Summary

The purpose of this study is to investigate the effect of comprehensive swallowing rehabilitation in patients with multiple system atrophy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age >19 years

  • Clinically diagnosed with MSA according to the guidelines of the 2nd consensus ofthe Gilman criteria

  • Clinically diagnosed to have dysphagia by a physiatrist

  • Two or more points on the Penetration-aspiration scale (PAS) from theVideofluoroscopic swallowing study (VFSS) conducted within 3 months

Exclusion

Exclusion Criteria:

  • Moderate to severe cognitive dysfunction with Mini-mental State Examination score < 19

  • Comorbidities or structural abnormalities that may affect swallowing function

  • Other comorbidities that make it difficult to participate in the study

Study Design

Total Participants: 24
Treatment Group(s): 2
Primary Treatment: Comprehensive swallowing rehabilitation
Phase:
Study Start date:
May 17, 2021
Estimated Completion Date:
December 31, 2025

Study Description

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease characterized by parkinsonism, cerebellar syndrome, and autonomic failure. Dysphagia is a clinically significant symptom leading to pneumonia that causes death in patients with MSA. Although the symptoms of dysphagia in the two subtypes of MSA-the parkinsonian variant and the cerebellar variant- are different, there is no significant difference in the latency to onset of tube feeding. Therefore, effective intervention is needed to improve the safety and efficiency of swallowing regardless of the subtypes of MSA.

Although swallowing rehabilitation has been widely applied for swallowing disorders in patients with MSA, few studies have reported the clinical effect of applying swallowing therapy. Comprehensive swallowing rehabilitation has focused on functional muscle training, compensatory swallowing maneuvers, and thermal-tactile stimulation, which is used to treat dysphagia from stroke, Parkinson's disease, and head and neck cancer. Therefore, this study aims to investigate the effect of comprehensive swallowing rehabilitation in patients with MSA.

Connect with a study center

  • Seoul National University Hospital

    Seoul, 03080
    Korea, Republic of

    Active - Recruiting

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