Hippocampal Response to Acute Oral Doses of CBD During an fMRI Memory Task

Inclusion Criteria:

• 18-50y/o
• Males and females of all races and ethnicities
• Able to provide written informed consent
• Able to read, speak, and understand English
• Meet DSM-IV (SCID-based) criteria for schizophrenia, schizoaffective disorder, bipolarI disorder with psychotic features OR healthy controlled with no diagnosed severemental illness
• No history of adverse normal baseline values for liver function tests (LFTs)

Exclusion Criteria:

• Strongly left-handed individuals defined as a 60:40 or greater ratio of left to righthand preference (assessed using the Edinburgh Handedness Inventory)
• Premorbid intellectual ability estimate below 70 (WRAT-4, Word Reading subtest,age-corrected standardized score)
• Comorbid DSM-IV diagnosis of alcohol or substance abuse in prior 1 month or substancedependence in prior 3 months
• Neurological (e.g., seizure disorder, stroke, traumatic brain injury with a loss ofconsciousness ≥ 30min) or severe medical condition (e.g., decompensated cardiovasculardisorder, AIDS) that may affect central nervous system function
• Concomitant medications that may interact with study drug adversely such as plateletinhibitors, benzodiazepines, or valproate
• Initial detection of abnormal liver function tests or previous medical history ofabnormal liver function or liver disease
• Vulnerable populations (e.g., pregnant, nursing, incarcerated); unwilling to usereliable means of contraception
• High risk for suicide defined as more than 1 attempt in past 12 months that requiredmedical attention, any attempt in the past 3 months or current suicidal ideation withplan and intent such that outpatient care is precluded
• Current homicidal ideation with plan and intent such that outpatient care is precluded
• Positive result on breathalyzer or positive urine toxicology test for any substance,including CBD
• History of prior allergic reaction with CBD or CBD-containing products