Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated

Key Inclusion Criteria:

• Individuals with confirmation of acute myeloid leukemia (AML) by World HealthOrganization criteria, previously untreated for AML, and who have presence of atleast 1 TP53 gene mutation that is not benign or likely benign based on evaluationby either central laboratory or an approved local laboratory (after central reviewof the bone marrow TP53 mitigation next-generation sequencing test results) (individuals with biallelic 17p deletions, loss of both 17p alleles, are eligiblebased on locally evaluated cytogenetics/karyotype/fluorescence in situ hybridization (FISH) report).

• Individuals with white blood cell (WBC) count ≤ 20×10^3/microliter (μL) prior torandomization. If the individual's WBC is > 20×10^3/μL prior to randomization, theindividual can be enrolled, assuming all other eligibility criteria are met.However, the WBC should be ≤ 20×10^3/μL prior to the first dose of study treatmentand prior to each magrolimab dose the first 4 weeks (if the individual is randomizedto the experimental arm) Note: Individuals can be treated with hydroxyurea and/orleukapheresis throughout the study or prior to randomization to reduce the WBC to ≤ 20×10^3/μL to enable eligibility for study drug dosing.

• The hemoglobin must be ≥ 9 grams per deciliter (g/dL) prior to initial dose of studytreatment.

Notes: Transfusions are allowed to meet hemoglobin eligibility.

• Individual has provided informed consent.

• Individual is willing and able to comply with clinic visits and procedure outlinedin the study protocol.

• Individuals must have an Eastern Cooperative Oncology Group (ECOG) performancestatus of 0 to 2, except for individuals less than 75 years of age and appropriatefor non-intensive treatment. For these individuals, the ECOG performance statusscore may be 0 to 3.

• Individuals must have adequate renal function as demonstrated by a creatinineclearance ≥ 30 milliliters per minute calculated by the Cockcroft Gault formula.

• Adequate cardiac function as demonstrated by:

• Lack of symptomatic congestive heart failure and clinically significant cardiacarrhythmias and ischemic heart disease.

• Left ventricular ejection fraction (LVEF) > 50% for individuals appropriate forintensive therapy.

• Adequate liver function as demonstrated by:

• Aspartate aminotransferase ≤ 3.0 × upper limit of normal (ULN).

• Alanine aminotransferase ≤ 3.0 × ULN.

• Total bilirubin ≤ 1.5 × ULN, or primary unconjugated bilirubin ≤ 3.0 × ULN ifindividual has a documented history of Gilbert's syndrome or geneticequivalent.

• Pretreatment blood cross-match completed.

• Males and females of childbearing potential who engage in heterosexual intercoursemust agree to use protocol-specified method(s) of contraception.

• Individuals must be willing to consent to mandatory pretreatment and on-treatmentbone marrow biopsies (aspirate and trephines).

Key Exclusion Criteria:

• Positive serum pregnancy test.

• Breastfeeding female.

• Known hypersensitivity to any of the study drugs, the metabolites, or formulationexcipient.

• Prior treatment with any of the following:

• Cluster of differentiation 47 (CD47) or signal regulatory protein alpha (SIRPα)-targeting agents

• Antileukemic therapy for the treatment of AML (excluding hydroxyurea),hypomethylating agent (HMA), low dose cytarabine and/or venetoclax.

Note: Individuals with prior myelodysplastic syndrome (MDS) who have not received prior HMAs or chemotherapeutic agents for MDS are allowed on study. Other prior MDS therapies including, but not limited to, lenalidomide, erythroid stimulating agents, or similar red blood cell (RBC)-direct therapies, were allowed. Localized non-central nervous system (CNS) radiotherapy, erythroid and/or myeloid growth factors, hormonal therapy with luteinizing hormone-releasing hormone agonists for prostate cancer, hormonal therapy or maintenance for breast cancer, and treatment with bisphosphonates and receptor activator of nuclear factor kappa-B ligand inhibitors are also not criteria for exclusion.

• Individuals who are appropriate for intensive treatment but who have been previouslytreated with maximum cumulative doses of idarubicin and/or other anthracyclines andanthracenediones will be excluded.

• Individuals receiving any live vaccine within 4 weeks prior to initiation of studytreatments.

• For individuals appropriate for intensive therapy, individuals treated withtrastuzumab within 7 months prior to initiation of study treatments.

• Current participation in another interventional clinical study.

• Known inherited or acquired bleeding disorders.

• Individuals appropriate for non-intensive therapy, who have received treatment withstrong and/or moderate cytochrome P450 enzyme 3A (CYP3A) inducers within 7 daysprior to the initiation of study treatments.

• Individuals appropriate for non-intensive therapy who have consumed grapefruit,grapefruit products, Seville oranges (including marmalade containing Sevilleoranges) or starfruit within 3 days prior to the initiation of study treatment.

• Individuals appropriate for non-intensive therapy who have malabsorption syndrome orother conditions that preclude enteral route of administration.

• Clinical suspicion of active CNS involvement with AML.

• Individuals who have acute promyelocytic leukemia.

• Significant disease or medical conditions, as assessed by the investigator andsponsor, that would substantially increase the risk-benefit ratio of participatingin the study. This includes, but is not limited to, acute myocardial infarctionwithin the last 6 months, unstable angina, uncontrolled diabetes mellitus,significant active infections, and congestive heart failure New York HeartAssociation Class III-IV.

• Second malignancy, except MDS, treated basal cell or localized squamous skincarcinomas, localized prostate cancer, or other malignancies for which individualsare not on active anti-cancer therapies and have had no evidence of activemalignancy for at least ≥ 1 year Note: Individuals on maintenance therapy alone whohave no evidence of active malignancy for at least ≥ 1 year are eligible.

• Known active or chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infectionor human immunodeficiency virus (HIV) infection in medical history.

• Active HBV, and/or active HCV, and/or HIV following testing at screening:

• Individuals who test positive for hepatitis B surface antigen (HBsAg).Individuals who test positive for hepatitis B core antibody (anti-HBc) willrequire HBV deoxyribose nucleic acid (DNA) by quantitative polymerase chainreaction (PCR) for confirmation of active disease.

• Individuals who test positive for HCV antibody. These individuals will requireHCV ribose nucleic acid (RNA) quantitative PCR for confirmation of activedisease.

• Individuals who test positive for HIV antibody.

• Individuals not currently receiving antiviral therapy and who have anundetectable viral load in the prior 3 months may be eligible for the study.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.