Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System

Inclusion Criteria:

• Each potential subject must be an appropriate candidate for mobile bearing TAR byhaving: a primary osteoarthritis, post-traumatic osteoarthritis, or arthritissecondary to inflammatory disease, as determined by the Principle Investigator.

• Willingness to participate in the study and follow-up visits

• Written informed consent, including authorization to release collected health data

Exclusion Criteria:

• Skeletal immaturity

• Bone stock inadequate to support the device including:

• Severe osteoporotic or osteopenic condition or other conditions resulting inpoor bone quality

• Avascular necrosis of the talus

• Active or prior deep infection in the ankle joint or adjacent bones

• Malalignment or severe deformity of involved or adjacent anatomic structuresincluding:

• Hindfoot or forefoot malalignment precluding plantigrade foot

• Significant malalignment of the knee joint

• Insufficient ligament support that cannot be repaired with soft tissuestabilization (syndesmosis disruption)

• Charcot joint or peripheral neuropathy that may lead to Charcot joint of theaffected ankle

• Neuromuscular disease resulting in lack of normal muscle function about the affectedankle

• Lower extremity vascular insufficiency demonstrated by Doppler arterial pressure

• Poor skin and soft tissue quality about the surgical site

• Immunosupressive therapy

• Prior ankle fusion or revision of total ankle replacement

• High demanding sport activities (e.g., contact sports, jumping)

• Suspected or documented metal allergy or intolerance

• Condition or situation which, in the Physician's opinion, puts the subject atsignificant risk, or may interfere significantly with the subject's participation inthe study