The Significance of Peripheral Input

Phase

N/A

Condition

Oral Facial Pain

Pain

Pain (Pediatric)

Treatment

N/A

Clinical Study ID

NCT04764045

NP-FM-19

Ages > 18
All Genders

Study Summary

The investigators want to examine trigger point injections of local anesthetics, in patients with post operative neuropathic pain, determine changes in sensory disturbances such as allodynia, hyperalgesia and thermal sensitivity and examine whether trigger point injections will attenuate pain in rest and activity.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age > 18 years old
Patients with chronic pain (daily VAS pain scores >30 mm) for at least 3 months afterknee, shoulder or foot surgery
Patients with at least one identifiable trigger point in relation to incision from theknee, shoulder or foot surgery. A trigger point is defined as an ar-ea in relation tothe incision from surgery, in which a light pressure from a cotton pin radiate pain tothe nearby area, and exudes a motor reflex causing withdrawal of the leg
A written informed consent to participate in the study after having fully understoodthe contents of the protocol and restrictions

Exclusion

Exclusion Criteria:

Patients who cannot cooperate
Patients who cannot understand or speak Danish.
Patients with allergy to the drugs used in the study
Patients in treatment with vitamin K antagonists.
Patients with other pain conditions
Patients with diabetes

Study Design

November 20, 2019

May 01, 2021

Study Description

The presence of cutaneous trigger points in the surgical incision of patients with post-surgery pain has been shown in our pain clinic, all patients have persistent pain for more than 3 month and different sensory disturbances.

Examinations with trigger point injections of local anesthetics have been used to determine the influence of peripheral changes and the significance of afferent input on persistent post-surgery neuropathic pain.

In the present study the investigators will document the influence of cutaneous trigger point injections for both subjective pain experience and objective findings in the area such as allodynia, hyperalgesia and thermal sensitivity. The investigators expect reduction in spontaneous pain intensity and de-crease in peripheral sensory disturbances and will determine the significance of peripheral input in persistent neuropathic pain.

The investigators aim to investigate whether injection of local anesthesia into trigger points compared with placebo (saline) injection will attenuate pain and normalize abnormal sensations, such as hyperalgesia and allodynia. The investigators believe this to be an important investigation to understand the mechanisms behind chronic post-surgery pain.

Connect with a study center

Bispebjerg Hospital
Copenhagen, 2400 NV
Denmark
Active - Recruiting

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