Effectiveness of Sodium Hyaluronate In Relieving Nasal Symptoms Of Children With Seasonal Allergic Rhinitis

Inclusion Criteria:

• Pediatric patients between 6 to 12-year-old;
• Children must have a clinical history concordant to seasonal allergic rhinitis of theprevious year;
• Children must have skin prick test (SPT) positivity to pollen (tree, grass, or weed) (Positive SPT is defined as; skin reaction with within 15 minutes after the test and 3mm larger swelling compared to the negative control test; ALK, Hørsholm, Denmark)
• Children must have a total nasal symptom score (TNSS) of 4 or more on 4 of 7 daysduring the run-in period.

Exclusion Criteria:

• Children who were treated with systemic/topical nasal corticosteroids, antihistaminesor antibiotics, leukotriene receptor antagonists 4 weeks before the examination,
• those who had upper or lower respiratory tract infections;
• recipients of recent or ongoing allergen immunotherapy;
• active smokers;
• those with cystic fibrosis, immunodeficiency, septal deviation, nasal polyps, andostio-metal complex, exudation, abnormal nasal diagnostic function, nasal anatomicaldisorder, metabolic disease, or congenital disease.
• Phone calls will measure children's adherence rate to treatment protocols, andparticipants determined to have treatment protocol adherence rates below 85% will beexcluded.