IDEAL Blood Pressure Management During Endovascular Therapy for Acute Ischemic Stroke

Last updated: June 10, 2022
Sponsor: University of Aarhus
Overall Status: Completed

Phase

N/A

Condition

Blood Clots

Stroke

Occlusions

Treatment

N/A

Clinical Study ID

NCT04749251
IDEAL BP Feasibility Study
  • Ages > 18
  • All Genders

Study Summary

The ideal blood pressure management strategy during endovascular therapy (EVT) for acute ischemic stroke has not been defined. The aim of this pilot randomized clinical trial is to determine whether randomization to a standard versus individual blood pressure management strategy during the EVT procedure is feasible.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Large vessel occlusion in anterior circulation in patients deemed treatable with EVT.
  • Living independently (mRS < 2) before stroke.
  • EVT procedure feasible within 24 hours of symptom onset.

Exclusion

Exclusion Criteria:

  • Contra-indication/allergy to contrast agents, vasopressor agents or anaesthetics.
  • Pregnancy.
  • Medical condition where blood pressure targeting will be problematic (aortadissection, etc).
  • Participation in another trial.

Study Design

Total Participants: 60
Study Start date:
April 01, 2021
Estimated Completion Date:
January 16, 2022

Study Description

Acute ischemic stroke (AIS) is a leading cause of death and long-term disability in the Western world. Catheter-based removal of blood clots (endovascular therapy-EVT) is now the standard of care for AIS caused by large vessel occlusions in the brain. The level of blood pressure during the procedure appears to influence outcome. However, optimal blood pressure management strategy has not been determined. Current blood pressure management strategy during EVT typically aims to maintain blood pressure above or within predefined fixed targets and is based on observational data and expert consensus rather than on high-quality randomized evidence. Should blood pressure during removal of the occlusion be managed according to the patient's individual blood pressure level or according to predefined fixed blood pressure targets? The primary aim of this pilot trial is to determine whether randomization to a procedure strategy targeting a predefined mean arterial blood pressure (MABP) of 70-90 mmHg versus an individual strategy targeting ± 10 % of a MABP reference value is feasible. Secondary aims are to test recruitability and to detect challenges or obstacles that would call for changes in the study design.

Connect with a study center

  • Aarhus University Hospital

    Aarhus, 8200
    Denmark

    Site Not Available

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