Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma

Last updated: February 22, 2024
Sponsor: Christopher Zachary
Overall Status: Active - Recruiting

Phase

N/A

Condition

Warts

Carcinoma

Cancer/tumors

Treatment

1064 nm long-pulse Nd:YAG laser

Clinical Study ID

NCT04744935
20205664
  • Ages 18-99
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Optical coherence tomography guided laser treatment of basal cell carcinoma

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Ability to understand and carry out subject instructions or be represented by alegally authorized guardian or representative
  • Ages 18 and older
  • Seeks and is scheduled for treatment of a BCC previously confirmed with biopsy

Exclusion

Exclusion Criteria: Any of the following will exclude participation in the study:

  • Inability to understand and/or carry out instructions
  • Patients with a BCC lesion that requires excision. This would include relatively largelesions (>2.5 cm diameter), lesions that penetrate deep into the skin beyond the depthof the OCT image capture, high risk lesions as defined by the American Academy ofDermatology as recurrent and sclerosing subtype BCC, or metastases.
  • Patients with periocular BCCs which might expose the patient to risk of damage to eyesfrom the laser.
  • BCCs on legs due to their tendency towards poor wound healing.
  • Pregnancy
  • Patients unable to follow-up for the full 12 months.

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: 1064 nm long-pulse Nd:YAG laser
Phase:
Study Start date:
January 13, 2021
Estimated Completion Date:
December 31, 2025

Study Description

The purpose of this pilot study is to examine the treatment basal cell carcinoma (BCC) with laser technology under the guidance of optical coherence tomography imaging (OCT). The laser modality that we plan to use is the long-pulse Nd:YAG 1064nm laser, which is a non-ablative laser already shown to effectively treat BCC. Laser treatment of BCC has limited precedent in the literature, but the addition of OCT has the opportunity to enhance outcomes by better targeting the treatment and permitting more precise monitoring of clearance. We propose to use OCT imaging to guide the laser treatment to achieve optimal efficacy with minimized side-effects.

Connect with a study center

  • UCI Health Gottschalk Medical Plaza

    Irvine, California 92617
    United States

    Active - Recruiting

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