HIP Fracture Accelerated Surgical TreaTment and Care TracK 2 Trial

Last updated: March 25, 2025
Sponsor: Population Health Research Institute
Overall Status: Active - Recruiting

Phase

N/A

Condition

Myocardial Ischemia

Osteoporosis

Treatment

Accelerated medical clearance and surgery

Clinical Study ID

NCT04743765
v2.0_20230608
  • Ages > 45
  • All Genders

Study Summary

The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in reducing death at 90 days after randomization. The trial will also assess secondary outcomes at 90 days after randomization: inability to independently walk 3 metres, time to first mobilization (first standing and first full weight bear), composite and individual assessment of major complications (e.g., mortality, non-fatal myocardial infarction, acute congestive heart failure, and stroke), delirium, length of stay, pain, and quality of life.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. age ≥45 years;

  2. diagnosis of hip fracture during working hours with a low-energy mechanism requiringsurgery;

  3. troponin elevation ( at least one troponin measurement above the upper limit ofnormal occurring from the time of hip fracture to the time of randomization); and

  4. informed consent.

Exclusion

Exclusion Criteria:

  1. taking a therapeutic dose of an anticoagulant for which no reversing agent isavailable and the anesthesiologist or surgeon believe surgery within 6 hours ofeligibility criteria met would not be safe;

  2. patients on a therapeutic vitamin K antagonist with a history of heparin inducedthrombocytopenia (HIT);

  3. patients with peri-prosthetic fracture, open fracture or bilateral fractures;

  4. patients requiring an emergency surgery for another reason (e.g., subduralhematoma);

  5. patients with acute myocardial infarction deemed to be clinically unstable, with amechanical complication (i.e., acute papillary muscle rupture, ventricular septaldefect), ST elevation myocardial infarction, or cardiogenic shock;

  6. patients refusing consent; or

  7. patients previously enrolled in HIP ATTACK-2.

Study Design

Total Participants: 1100
Treatment Group(s): 1
Primary Treatment: Accelerated medical clearance and surgery
Phase:
Study Start date:
November 22, 2021
Estimated Completion Date:
May 31, 2027

Connect with a study center

  • The John Hunter Hospital

    New Lambton Heights, New South Wales 2305
    Australia

    Active - Recruiting

  • Cliniques Universitaires Saint Luc - University Catholic of Louvain

    Woluwe-Saint-Lambert, Brussels 1200
    Belgium

    Active - Recruiting

  • University of São Paulo

    São Paulo, SP 05403010
    Brazil

    Active - Recruiting

  • University of Alberta Hospital

    Edmonton, Alberta T6G 2B7
    Canada

    Active - Recruiting

  • Juravinski Hospital

    Hamilton, Ontario L8V 1C3
    Canada

    Active - Recruiting

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario L8N 4A6
    Canada

    Active - Recruiting

  • Victoria Hospital

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

  • Markham Stouffville Hospital

    Markham, Ontario L3P 7P3
    Canada

    Active - Recruiting

  • Ottawa General Hospital

    Ottawa, Ontario K1H 8L6
    Canada

    Active - Recruiting

  • Pontifica Universidad Catolica de Chile

    Santiago, RM 83300024
    Chile

    Active - Recruiting

  • Clinica Santa Maria

    Santiago, 7520378
    Chile

    Active - Recruiting

  • South Karelia Central Hospital

    Lappeenranta, 53130
    Finland

    Active - Recruiting

  • Tampere University Hospital

    Tampere, 33521
    Finland

    Active - Recruiting

  • Queen Mary Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • All India Institute of Medical Sciences (AIIMS)

    New Delhi, Delhi 110029
    India

    Active - Recruiting

  • Bangalore Baptist Hospital

    Bangalore, Karnataka 560024
    India

    Active - Recruiting

  • Government TD Medical College

    Alappuzha, Kerala 688005
    India

    Active - Recruiting

  • JIPMER

    Pondicherry, 605006
    India

    Active - Recruiting

  • IRCCS Ospedale Galeazzi- Sant'Ambrogio

    Milan,
    Italy

    Active - Recruiting

  • Ospedale Galeazzi SpA

    Milan, 20157
    Italy

    Active - Recruiting

  • Ospedale San Raffaele S.r.l.

    Milan, 20132
    Italy

    Active - Recruiting

  • University of Malaya Medical Centre

    Kuala Lumpur, 59100
    Malaysia

    Active - Recruiting

  • Cruz Verde Guadalajara

    Guadalajara, Jalisco 44410
    Mexico

    Active - Recruiting

  • Christus Muguerza del Parque

    Chihuahua, 31000
    Mexico

    Active - Recruiting

  • B and B Hospital

    Lalitpur, Bagmati 44700
    Nepal

    Active - Recruiting

  • Deventer Hospital

    Deventer, Overijssel 7416 SE
    Netherlands

    Active - Recruiting

  • Stichting OLVG

    Amsterdam,
    Netherlands

    Active - Recruiting

  • Maroof International Hospital

    Islamabad, ICT 44000
    Pakistan

    Active - Recruiting

  • Shifa International Hospitals Ltd.

    Islamabad, ICT 44000
    Pakistan

    Active - Recruiting

  • Hayat Abad Medical Complex

    Peshawar, KPK 25000
    Pakistan

    Active - Recruiting

  • Ghurki Trust Teaching Hospital

    Lahore, Punjab 54000
    Pakistan

    Active - Recruiting

  • Combined Military Hospital

    Rawalpindi, Punjab 46000
    Pakistan

    Active - Recruiting

  • Indus Hospital & Health Network

    Karachi, Sind
    Pakistan

    Active - Recruiting

  • Aga Khan University

    Karachi, Sindh 74800
    Pakistan

    Active - Recruiting

  • SPZOZ Myslenice

    Myslenice, Malopolska 32-400
    Poland

    Active - Recruiting

  • King Faisal Specialist Hospital

    Riyadh, 11211
    Saudi Arabia

    Active - Recruiting

  • Groote Schuur Hospital

    Cape Town, Western Cape 7925
    South Africa

    Active - Recruiting

  • Stellenbosch University - Tygerberg Hospital

    Cape Town, Western Cape 7505
    South Africa

    Active - Recruiting

  • Hospital Universitari Parc Tauli

    Sabadell, Barcelona 08208
    Spain

    Active - Recruiting

  • Hospital Sant Camil

    Sant Pere De Ribes, Barcelona 08810
    Spain

    Active - Recruiting

  • Hospital Universitario Mutua de Terrassa

    Terrassa, Barcelona 08221
    Spain

    Active - Recruiting

  • Hospital Costa del Sol

    Marbella, Malaga 29603
    Spain

    Active - Recruiting

  • Hospital Clinic of Barcelona

    Barcelona, 08036
    Spain

    Active - Recruiting

  • Hospital Universitari Sagrat Cor

    Barcelona, 08029
    Spain

    Active - Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Active - Recruiting

  • Hospital de la Santa Creu I Sant Pau

    Barcelona, 08041
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario de Vallad

    Valladolid, 47007
    Spain

    Active - Recruiting

  • The Regents of the University of California

    Davis, California 95618
    United States

    Active - Recruiting

  • Yale New Haven Hospital

    New Haven, Connecticut 06520
    United States

    Active - Recruiting

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215
    United States

    Active - Recruiting

  • University of Maryland

    Baltimore, Maryland 20742
    United States

    Active - Recruiting

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Active - Recruiting

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Active - Recruiting

  • Bryan Medical Center

    Lincoln, Nebraska 68506
    United States

    Active - Recruiting

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756
    United States

    Active - Recruiting

  • Montefiore Medical Center

    Bronx, New York 10467
    United States

    Active - Recruiting

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • St. Luke's University Health Network

    Bethlehem, Pennsylvania 18015
    United States

    Active - Recruiting

  • University of Wisconsin

    Madison, Wisconsin 53715
    United States

    Active - Recruiting

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