HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

Last updated: September 25, 2025
Sponsor: Population Health Research Institute
Overall Status: Active - Recruiting

Phase

N/A

Condition

Myocardial Ischemia

Osteoporosis

Treatment

Accelerated medical clearance and surgery

Clinical Study ID

NCT04743765
v2.0_20230608
  • Ages > 45
  • All Genders

Study Summary

The HIP ATTACK-2 trial is a multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in reducing death at 90 days after randomization. The trial will also assess secondary outcomes at 90 days after randomization: inability to independently walk 3 metres, time to first mobilization (first standing and first full weight bear), composite and individual assessment of major complications (e.g., mortality, non-fatal myocardial infarction, acute congestive heart failure, and stroke), delirium, length of stay, pain, and quality of life.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. age ≥45 years;

  2. diagnosis of hip fracture during working hours with a low-energy mechanism requiringsurgery;

  3. troponin elevation ( at least one troponin measurement above the upper limit ofnormal occurring from the time of hip fracture to the time of randomization); and

  4. informed consent.

Exclusion

Exclusion Criteria:

  1. taking a therapeutic dose of an anticoagulant for which no reversing agent isavailable and the anesthesiologist or surgeon believe surgery within 6 hours ofeligibility criteria met would not be safe;

  2. patients on a therapeutic vitamin K antagonist with a history of heparin inducedthrombocytopenia (HIT);

  3. patients with peri-prosthetic fracture, open fracture or bilateral fractures;

  4. patients requiring an emergency surgery for another reason (e.g., subduralhematoma);

  5. patients with acute myocardial infarction deemed to be clinically unstable, with amechanical complication (i.e., acute papillary muscle rupture, ventricular septaldefect), ST elevation myocardial infarction, or cardiogenic shock;

  6. patients refusing consent; or

  7. patients previously enrolled in HIP ATTACK-2.

Study Design

Total Participants: 1100
Treatment Group(s): 1
Primary Treatment: Accelerated medical clearance and surgery
Phase:
Study Start date:
November 22, 2021
Estimated Completion Date:
May 31, 2027

Connect with a study center

  • The John Hunter Hospital

    New Lambton Heights, New South Wales 2305
    Australia

    Site Not Available

  • The John Hunter Hospital

    New Lambton Heights 10103866, New South Wales 2155400 2305
    Australia

    Active - Recruiting

  • Cliniques Universitaires Saint Luc - University Catholic of Louvain

    Woluwe-Saint-Lambert, Brussels 1200
    Belgium

    Site Not Available

  • Cliniques Universitaires Saint Luc - University Catholic of Louvain

    Woluwe-Saint-Lambert 2783476, Brussels Capital 2800867 1200
    Belgium

    Active - Recruiting

  • University of São Paulo

    São Paulo, SP 05403010
    Brazil

    Site Not Available

  • University of São Paulo

    São Paulo 3448439, São Paulo 3448433 05403010
    Brazil

    Active - Recruiting

  • University of Alberta Hospital

    Edmonton, Alberta T6G 2B7
    Canada

    Site Not Available

  • University of Alberta Hospital

    Edmonton 5946768, Alberta 5883102 T6G 2B7
    Canada

    Active - Recruiting

  • Juravinski Hospital

    Hamilton, Ontario L8V 1C3
    Canada

    Active - Recruiting

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario L8N 4A6
    Canada

    Site Not Available

  • Victoria Hospital

    London, Ontario N6A 5W9
    Canada

    Site Not Available

  • Markham Stouffville Hospital

    Markham, Ontario L3P 7P3
    Canada

    Site Not Available

  • Ottawa General Hospital

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • Juravinski Hospital

    Hamilton 5969782, Ontario 6093943 L8V 1C3
    Canada

    Active - Recruiting

  • St. Joseph's Healthcare Hamilton

    Hamilton 5969782, Ontario 6093943 L8N 4A6
    Canada

    Active - Recruiting

  • Victoria Hospital

    London 6058560, Ontario 6093943 N6A 5W9
    Canada

    Active - Recruiting

  • Markham Stouffville Hospital

    Markham 6066513, Ontario 6093943 L3P 7P3
    Canada

    Active - Recruiting

  • Ottawa General Hospital

    Ottawa 6094817, Ontario 6093943 K1H 8L6
    Canada

    Active - Recruiting

  • CISSS de Laval

    Laval, Quebec H7M 3L9
    Canada

    Site Not Available

  • CISSS de Laval

    Laval 6050610, Quebec 6115047 H7M 3L9
    Canada

    Active - Recruiting

  • Pontifica Universidad Catolica de Chile

    Santiago, RM 83300024
    Chile

    Site Not Available

  • Pontifica Universidad Catolica de Chile

    Santiago 3871336, RM 83300024
    Chile

    Active - Recruiting

  • Clinica Santa Maria

    Santiago, 7520378
    Chile

    Active - Recruiting

  • Clinica Santa Maria

    Santiago 3871336, 7520378
    Chile

    Active - Recruiting

  • South Karelia Central Hospital

    Lappeenranta, 53130
    Finland

    Site Not Available

  • South Karelia Central Hospital

    Lappeenranta 648900, 53130
    Finland

    Active - Recruiting

  • Tampere University Hospital

    Tampere, 33521
    Finland

    Site Not Available

  • Tampere University Hospital

    Tampere 634963, 33521
    Finland

    Active - Recruiting

  • Queen Mary Hospital

    Hong Kong,
    Hong Kong

    Site Not Available

  • Queen Mary Hospital

    Hong Kong 1819729,
    Hong Kong

    Active - Recruiting

  • All India Institute of Medical Sciences (AIIMS)

    New Delhi, Delhi 110029
    India

    Site Not Available

  • Bangalore Baptist Hospital

    Bangalore, Karnataka 560024
    India

    Site Not Available

  • Bangalore Baptist Hospital

    Bangalore 1277333, Karnataka 1267701 560024
    India

    Active - Recruiting

  • Government TD Medical College

    Alappuzha, Kerala 688005
    India

    Site Not Available

  • Government Medical College

    Trivandrum, Kerala 695011
    India

    Site Not Available

  • Government TD Medical College

    Alappuzha 1278985, Kerala 1267254 688005
    India

    Active - Recruiting

  • Government Medical College

    Trivandrum 1254163, Kerala 1267254 695011
    India

    Active - Recruiting

  • All India Institute of Medical Sciences (AIIMS)

    New Delhi 1261481, National Capital Territory of Delhi 1273293 110029
    India

    Active - Recruiting

  • JIPMER

    Puducherry 1259425, Puducherry 1259424 605006
    India

    Active - Recruiting

  • JIPMER

    Pondicherry, 605006
    India

    Site Not Available

  • Hospital of Perugia

    Perugia, Umbria 06129
    Italy

    Site Not Available

  • Hospital of Perugia

    Perugia 3171180, Umbria 3165048 06129
    Italy

    Active - Recruiting

  • Galliera Hospital

    Genova, 16128
    Italy

    Site Not Available

  • Galliera Hospital

    Genova 8969657, 16128
    Italy

    Active - Recruiting

  • IRCCS Ospedale Galeazzi- Sant'Ambrogio

    Milan,
    Italy

    Active - Recruiting

  • Ospedale Galeazzi SpA

    Milan, 20157
    Italy

    Site Not Available

  • Ospedale San Raffaele S.r.l.

    Milan, 20132
    Italy

    Active - Recruiting

  • Ospedale Galeazzi SpA

    Milan 3173435, 20157
    Italy

    Active - Recruiting

  • Ospedale San Raffaele S.r.l.

    Milan 3173435, 20132
    Italy

    Active - Recruiting

  • University of Malaya Medical Centre

    Kuala Lumpur, 59100
    Malaysia

    Site Not Available

  • University of Malaya Medical Centre

    Kuala Lumpur 1735161, 59100
    Malaysia

    Active - Recruiting

  • Christus Muguerza del Parque

    Chihuahua City 4014338, Chihuahua 4014336 31000
    Mexico

    Active - Recruiting

  • Cruz Verde Guadalajara

    Guadalajara, Jalisco 44410
    Mexico

    Site Not Available

  • Cruz Verde Guadalajara

    Guadalajara 4005539, Jalisco 4004156 44410
    Mexico

    Active - Recruiting

  • Christus Muguerza del Parque

    Chihuahua, 31000
    Mexico

    Site Not Available

  • B and B Hospital

    Lalitpur, Bagmati 44700
    Nepal

    Site Not Available

  • B and B Hospital

    Lalitpur 7957352, Bagmati 44700
    Nepal

    Active - Recruiting

  • Deventer Hospital

    Deventer, Overijssel 7416 SE
    Netherlands

    Site Not Available

  • Deventer Hospital

    Deventer 2756987, Overijssel 2748838 7416 SE
    Netherlands

    Active - Recruiting

  • Stichting OLVG

    Amsterdam,
    Netherlands

    Site Not Available

  • Stichting OLVG

    Amsterdam 2759794,
    Netherlands

    Active - Recruiting

  • Maroof International Hospital

    Islamabad, ICT 44000
    Pakistan

    Site Not Available

  • Shifa International Hospitals Ltd.

    Islamabad, ICT 44000
    Pakistan

    Active - Recruiting

  • Maroof International Hospital

    Islamabad 1176615, ICT 44000
    Pakistan

    Active - Recruiting

  • Shifa International Hospitals Ltd.

    Islamabad 1176615, ICT 44000
    Pakistan

    Active - Recruiting

  • Hayat Abad Medical Complex

    Peshawar, KPK 25000
    Pakistan

    Site Not Available

  • Hayat Abad Medical Complex

    Peshawar 1168197, KPK 25000
    Pakistan

    Active - Recruiting

  • Ghurki Trust Teaching Hospital

    Lahore, Punjab 54000
    Pakistan

    Site Not Available

  • Combined Military Hospital

    Rawalpindi, Punjab 46000
    Pakistan

    Site Not Available

  • Ghurki Trust Teaching Hospital

    Lahore 1172451, Punjab Province 1167710 54000
    Pakistan

    Active - Recruiting

  • Combined Military Hospital

    Rawalpindi 1166993, Punjab Province 1167710 46000
    Pakistan

    Active - Recruiting

  • Indus Hospital & Health Network

    Karachi, Sind
    Pakistan

    Site Not Available

  • Aga Khan University

    Karachi, Sindh 74800
    Pakistan

    Active - Recruiting

  • Aga Khan University

    Karachi 1174872, Sindh 1164807 74800
    Pakistan

    Active - Recruiting

  • Indus Hospital & Health Network

    Karachi 1174872, Sindh 1164807
    Pakistan

    Active - Recruiting

  • SPZOZ Myslenice

    Myslenice, Malopolska 32-400
    Poland

    Site Not Available

  • SPZOZ Myslenice

    Myślenice 3091256, Malopolska 32-400
    Poland

    Active - Recruiting

  • King Faisal Specialist Hospital

    Riyadh 108410, Riyadh Region 108411 11211
    Saudi Arabia

    Active - Recruiting

  • King Faisal Specialist Hospital

    Riyadh, 11211
    Saudi Arabia

    Site Not Available

  • Groote Schuur Hospital

    Cape Town, Western Cape 7925
    South Africa

    Active - Recruiting

  • Stellenbosch University - Tygerberg Hospital

    Cape Town, Western Cape 7505
    South Africa

    Site Not Available

  • Groote Schuur Hospital

    Cape Town 3369157, Western Cape 1085599 7925
    South Africa

    Active - Recruiting

  • Stellenbosch University - Tygerberg Hospital

    Cape Town 3369157, Western Cape 1085599 7505
    South Africa

    Active - Recruiting

  • Hospital Clinic of Barcelona

    Barcelona 3128760, Barcelona 08036
    Spain

    Active - Recruiting

  • Hospital Universitari Sagrat Cor

    Barcelona 3128760, Barcelona 08029
    Spain

    Active - Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona 3128760, Barcelona 08035
    Spain

    Active - Recruiting

  • Hospital de la Santa Creu I Sant Pau

    Barcelona 3128760, Barcelona 08041
    Spain

    Active - Recruiting

  • Hospital Universitari Parc Tauli

    Sabadell, Barcelona 08208
    Spain

    Site Not Available

  • Hospital Universitari Parc Tauli

    Sabadell 3111199, Barcelona 08208
    Spain

    Active - Recruiting

  • Hospital Sant Camil

    Sant Pere De Ribes, Barcelona 08810
    Spain

    Site Not Available

  • Hospital Sant Camil

    Sant Pere de Ribes 3110143, Barcelona 08810
    Spain

    Active - Recruiting

  • Hospital Universitario Mutua de Terrassa

    Terrassa, Barcelona 08221
    Spain

    Site Not Available

  • Hospital Universitario Mutua de Terrassa

    Terrassa 3108286, Barcelona 08221
    Spain

    Active - Recruiting

  • Hospital Costa del Sol

    Marbella, Malaga 29603
    Spain

    Site Not Available

  • Hospital Costa del Sol

    Marbella 2514169, Malaga 29603
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario de Vallad

    Valladolid 3106672, Valladolid 47007
    Spain

    Active - Recruiting

  • Hospital Clinic of Barcelona

    Barcelona, 08036
    Spain

    Active - Recruiting

  • Hospital Universitari Sagrat Cor

    Barcelona, 08029
    Spain

    Active - Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Active - Recruiting

  • Hospital de la Santa Creu I Sant Pau

    Barcelona, 08041
    Spain

    Active - Recruiting

  • Parc Sanitari Sant Joan de Déu

    Barcelona, 08830
    Spain

    Site Not Available

  • Parc Sanitari Sant Joan de Déu

    Barcelona 3128760, 08830
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario de Vallad

    Valladolid, 47007
    Spain

    Site Not Available

  • Chandler Regional Medical Center

    Chandler, Arizona 85224
    United States

    Site Not Available

  • Chandler Regional Medical Center

    Chandler 5289282, Arizona 5551752 85224
    United States

    Active - Recruiting

  • The Regents of the University of California

    Davis, California 95618
    United States

    Site Not Available

  • The Regents of the University of California

    Davis 5341704, California 5332921 95618
    United States

    Active - Recruiting

  • Yale New Haven Hospital

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • Yale New Haven Hospital

    New Haven 4839366, Connecticut 4831725 06520
    United States

    Active - Recruiting

  • Emory University at Grady Memorial Hospital

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • Emory University at Grady Memorial Hospital

    Atlanta 4180439, Georgia 4197000 30322
    United States

    Active - Recruiting

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215
    United States

    Site Not Available

  • University of Maryland

    Baltimore, Maryland 20742
    United States

    Active - Recruiting

  • Sinai Hospital of Baltimore

    Baltimore 4347778, Maryland 4361885 21215
    United States

    Active - Recruiting

  • University of Maryland

    Baltimore 4347778, Maryland 4361885 20742
    United States

    Active - Recruiting

  • Tufts Medical Center

    Boston, Massachusetts 02111
    United States

    Site Not Available

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • Tufts Medical Center

    Boston 4930956, Massachusetts 6254926 02111
    United States

    Active - Recruiting

  • Lahey Hospital and Medical Center

    Burlington 4931737, Massachusetts 6254926 01805
    United States

    Active - Recruiting

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • University of Michigan

    Ann Arbor 4984247, Michigan 5001836 48109
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

  • Bryan Medical Center

    Lincoln, Nebraska 68506
    United States

    Site Not Available

  • Bryan Medical Center

    Lincoln 5072006, Nebraska 5073708 68506
    United States

    Active - Recruiting

  • University Medical Center of Southern Nevada

    Las Vegas 5506956, Nevada 5509151 89102
    United States

    Active - Recruiting

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756
    United States

    Site Not Available

  • Dartmouth-Hitchcock Medical Center

    Lebanon 5088597, New Hampshire 5090174 03756
    United States

    Active - Recruiting

  • Montefiore Medical Center

    Bronx, New York 10467
    United States

    Site Not Available

  • Montefiore Medical Center

    The Bronx 5110266, New York 5128638 10467
    United States

    Active - Recruiting

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Cleveland Clinic

    Cleveland 5150529, Ohio 5165418 44195
    United States

    Active - Recruiting

  • Oregon Health and Science University

    Portland, Oregon 97239
    United States

    Site Not Available

  • Oregon Health and Science University

    Portland 5746545, Oregon 5744337 97239
    United States

    Active - Recruiting

  • St. Luke's University Health Network

    Bethlehem, Pennsylvania 18015
    United States

    Site Not Available

  • St. Luke's University Health Network

    Bethlehem 5180225, Pennsylvania 6254927 18015
    United States

    Active - Recruiting

  • The University of Texas Health Science Center at Houston

    Houston 4699066, Texas 4736286 77030
    United States

    Active - Recruiting

  • University of Wisconsin

    Madison, Wisconsin 53715
    United States

    Site Not Available

  • University of Wisconsin

    Madison 5261457, Wisconsin 5279468 53715
    United States

    Active - Recruiting

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