Phase
Condition
Cancer (Pediatric)
Neuroblastoma
Retinoblastoma
Treatment
Fisetin
Dasatinib plus Quercetin
Clinical Study ID
Ages > 18 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant in SJLIFE and > 5 years from diagnosis.
≥18 years of age.
Frail (2 of 4 objectively measured Fried criteria adapted,(excluding self-reportedfatigue as a criteria), including abnormal walking speed; muscle strength; activitylevel; and muscle mass). See Section 5 for details.
CD3+ T lymphocytes: p16INK4A detected at <34 cycles by RT PCR.
Agrees to use contraception as Dasatinib is teratogenic.
Female participant has a negative pregnancy test.
QTc <450 milliseconds in electrocardiogram.
Able to take oral medications.
Exclusion
Exclusion Criteria:
Currently has HIV, Hepatitis B/C, invasive fungal infection
Anemia or as per clinical judgement.
Hypersensitivity to study drugs
New/active malignancy/taking chemotherapy and/or radiation except non-melanoma skincancers
Currently taking medications that inhibit or induce CYP3A4 or that are sensitive tosubstrates or substrates with a narrow therapeutic range for CYP2C8, CYP2C9, orCYP2D6.
Taking anticoagulants or antimicrobial agents
Currently taking Quercetin or Fisetin
Pregnant or nursing at time of enrollment/during the study
Impaired cognition or motor performance due to congenital defects
Currently participating in another research intervention to aid walking speed orother measures of frailty including muscle strength; low activity; muscle mass orexhaustion/fatigue
Participant is a Non-English Speaker
Uncontrolled pleural/pericardial effusion or ascites
Subjects on anticoagulant or antiplatelet agents (Warfarin, Clopidogrel [Plavix];Dipyridamole + Aspirin [Aggrenox]; Ticagrelor [Brilintal]; Prasugrel [Effient];Ticlopidine [Ticlid]; or other) who are unable or unwilling to reduce or holdtherapy prior to and during the 2-3 day drug dosing. Subjects may continue theirprevious regimen after drug dosing is complete.
Cognitive impairment defined by IQ <80
Diagnosis of a psychotic disorder
Laboratory tests as indicated or as per clinical judgement
Severe hepatic dysfunction with ALT/AST > 3 times upper limit of normal.
Total bilirubin > 2 times upper limit of normal.
eGFR <25 ml/min/1.73m2 or as per clinical judgement.
Hemoglobin < 7 g/dl; white blood cell count ≤2,000/mm3 (≤2.0 x 109/L) or ≥20,000/mm3 (≥20 x 109/L); platelet count ≤40,000/μL (≤40 x 109/L); absolute neutrophil count ≤1x 109/L; lymphocyte count <0.3 x 109/L at screening as a marker of poor nutrition
Fasting glucose >300.
Participant is unable to ambulate
Study Design
Study Description
Connect with a study center
St. Jude Children's Research Hospital
Memphis, Tennessee 38105
United StatesActive - Recruiting
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