LUX-Dx Insertable Cardiac Monitor Remote Programming and Performance Study

Inclusion Criteria:

• Patient is indicated to be implanted with the LUX-Dx ICM for one of the followingreasons (grouped in three "Reason for Monitoring" subgroups): 1) Cryptogenic stroke,

2. Syncope, 3) AF management, Post-AF ablation, or Suspected AF

• Patient is willing to enroll and be monitored in LATITUDE Clarity.

• Patient is willing and able to be followed remotely via the ICM patient mobile app.

• Patient is willing and capable of providing informed consent (which is not toinclude the use of a legally authorized representative (LAR) for documentation ofinformed consent) and agrees to participate in all protocol required activities.

• Patient is age 18 years or above, or of legal age to give informed consent specificto state and national law.

The following inclusion criterion is applicable for patients participating in the Holter study:

• Patient can tolerate the adhesive used in the Holter monitoring for an extended period of time.

Exclusion Criteria:

• Patient is indicated for implantation of, or is currently implanted with an activeimplantable cardiac device (e.g., LVAD, ICD, CRT D, PPM*).

• Patient cannot tolerate a subcutaneous, chronically-inserted device due to medicalcondition.

• Patient has a documented life expectancy of less than 12 months (per investigator'sdiscretion).

• Patient is known to be pregnant at the time of study enrollment (method ofassessment upon investigator's discretion).

• Patient is currently enrolled in another clinical study including observationalstudies/registries, unless prior written approval from BSC is obtained. Mandatorygovernmental registries are accepted for co-enrollment without approval by BSC.

The following exclusion criteria are applicable for patients participating in the Holter study:

• Patient has known allergies to the adhesive materials or hydrogel used in theextended Holter monitoring.

• Patient has broken, damaged, or irritated skin over the chest area where theextended Holter monitor will be attached.