ENB-guided Ablation Therapy Combined With VATS in the Treatment of MPLC

Last updated: January 28, 2021
Sponsor: Shanghai Chest Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Non-small Cell Lung Cancer

Lung Cancer

Lung Disease

Treatment

N/A

Clinical Study ID

NCT04730453
SHCHE202101
  • All Genders

Study Summary

The study is designed as a prospective trial whose purpose is to evaluate the effectiveness and safety of ENB-guided ablation therapy combined with VATS in the treatment of multiple primary lung cancers (MPLC).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age ≥ 18 years old.
  2. The subject is diagnosed as multiple primary lung cancer via preoperativeimaging/pathological examination.
  3. Thin-slice CT images show that the ablation Lesion A is accessible/adjacent to bronchiand the size is ≤ 3 cm.
  4. The subject with multiple primary lung cancers can be treated with ENB-guided ablationtherapy combined with VATS according to multidisciplinary assessment.

Exclusion

Exclusion Criteria:

  1. The subject who cannot tolerate general anesthesia for their cardiopulmonary function,or there are other contraindications, such as uncorrectable coagulopathy.
  2. The situation in which the investigators think that the subject is not suitable toparticipate in this study.

Study Design

Total Participants: 30
Study Start date:
July 24, 2020
Estimated Completion Date:
December 31, 2025

Study Description

Patients will be first screened, and only after meeting all the selection criteria, not meeting any exclusion criteria, and signing the informed consent, could they be enrolled in the group to receive ENB-guided ablation therapy combined with VATS. The primary endpoint is objective response rate (ORR). The secondary endpoints include progression-free survival (PFS), overall survival (OS) and safety.

Connect with a study center

  • Shanghai Chest Hospital

    Shanghai, Shanghai 200030
    China

    Active - Recruiting

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