Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy

Inclusion Criteria:

• 1)18≤age≤60 years old, no gender limit; 2) Patients receiving routine gastroscopydiagnosis and treatment; 3) ASA score is I or II; 4) 18 kg/m2<BMI<28kg/m2； 5) It isestimated that the operation time of gastroscope will not exceed 30 minutes; 6) Clearlyunderstand, voluntarily participate in the research, and be signed and informed consent.

Exclusion Criteria:

1. Need to perform complicated endoscopic diagnosis and treatment techniques (such ascholangiopancreatography Surgery, endoscopic ultrasonography, endoscopic mucosalresection, endoscopic submucosa Stripping, oral endoscopic muscle dissection, etc.);
2. Patients who intend to undergo tracheal intubation;
3. It is judged to be difficult to manage the respiratory tract (modified Mallampatiscore is IV)patient;
4. Anemia or thrombocytopenia,( Hb<90g/L, PLT<80×109/L);
5. Diagnosed lung diseases (asthma, bronchitis, COPD, Pulmonary bullae,pulmonaryembolism, pulmonary edema, lung cancer);
6. Liver and kidney disease;( AST and/or ALT≥2.5×ULN,TBIL≥1.5×ULN, blood creatinine isgreater than the upper limit of normal);
7. There is a history of drug and/or alcohol abuse within 2 years before the beginning ofthe screening period.The average daily alcohol consumption exceeds 2 units of alcohol (1 unit = 360 mL beer Liquor or 45 mL liquor with 40% alcohol content or 150 mL grapesliqueur);
8. Hypertensive patients whose blood pressure has not been satisfactorily controlled byantihypertensive drugs(Sitting systolic blood pressure ≥160 mmHg during screeningperiod, and/or diastolic pressure during screening period Pressure ≥100 mmHg);
9. Sitting systolic blood pressure ≤90 mmHg during the screening period;
10. Women who are pregnant or breastfeeding;
11. Benzodiazepines, opioids, propofol, lidoca Those who are allergic or contraindicateddue to their drug components;
12. Participated in other drug clinical trials as subjects in the past 3 months;
13. The investigator believes that it is not appropriate to participate in this trial;
14. A well-diagnosed heart disease (heart failure, angina pectoris, myocardial infarction,heart rhythmabnormalities etc.).