JAB-3068 Activity in Adult Patients With Advanced Solid Tumors

Inclusion Criteria:

• Written informed consent, according to local guidelines, signed and dated by theparticipant prior to the performance of any study-specific procedures, sampling, oranalyses.

• Participant must be ≥18 years of age at the time of signature of the informedconsent form (ICF).

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.

Exclusion Criteria:

• History (≤3 years) of cancer that is histologically distinct from the cancers understudy, except for cervical carcinoma in situ, superficial non-invasive bladdertumors, or curatively treated Stage I non-melanoma skin cancer

• Known serious allergy to experimental drugs

• Brain or spinal metastases, except if treated by surgery, surgery plus radiotherapyor radiotherapy alone, with no evidence of progression or hemorrhage for ≤21 daysbefore the start of treatment with the study drugs, and has not received anysystemic corticosteroids for ≥21 days before the start of treatment with the studydrugs