UPenn Observational Research Repository on Neurodegenerative Disease

Inclusion Criteria:

This protocol will include 3 groups of people:

1. People with a clinical diagnosis of a neurodegenerative disease. such asfrontotemporal degeneration(FTD), primary progressive aphasia(PPA), Lewy bodydisease(LBD), amyotrophic lateral sclerosis(ALS), progressive supranuclearpalsy(PSP), corticobasal syndrome(CBS), posterior cortical atrophy(PCA), Alzheimer'sdisease(AD), Parkinson's disease(PD)

2. People with a family history of neurodegenerative disease who may or may not besymptomatic, and may or may not be mutation carriers such as familial frontotemporallobar degeneration (fFTLD) or familial ALS,

3. People with no known neurological disease who will provide control data.

Exclusion Criteria:

• Anyone who is under the age of 18.

• Anyone with a condition or in a situation which, in the Investigator's opinion,could confound the study findings or may interfere significantly with a person'sparticipation, including but not limited to neurological, psychological and othermedical conditions (such as cardiac, neurosurgical, infectious conditions).

• Individual participants may be excluded from some, but not all, study procedures forsafety reasons when they have a contraindication or at the discretion of theInvestigator. For example, persons with metal implants which are not MRI-safe willnot be able to take part in imaging, and those on blood thinning medications may notbe able to take part in lumbar puncture.

• Pregnant women; if a woman becomes pregnant during the study, research activitiesthat may increase risk to the patient and the unborn fetus will be stopped until theend of pregnancy, at which point participation can be resumed.