Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery

Inclusion Criteria:

• Subjects undergoing elective surgery (nonemergency, noncardiothoracic, andnonintracranial surgery anticipated to last at least 1 hour ).

• Males or females, aged ≥18 years old, with American Society of AnesthesiologistsPhysical Status (ASA PS) I to IV.

• Body mass index (BMI) ≥18 kg/m2.

• For all females of childbearing potential, negative pregnancy test at screening andbaseline. Additionally, females of childbearing potential must agree to use birthcontrol (such as condom, intrauterine device [IUD], abstinence) from the time ofconsent until 30 days post study drug administration.

• Capable of understanding the procedures and methods of this study, willing to signan Informed Consent Form, and to complete this study in strict compliance with thestudy protocol.

Exclusion Criteria:

• Contraindications to deep sedation/general anesthesia or a history of adversereaction to sedation/general anesthesia.

• Known to be allergic to eggs, soy products, opioids and their antidotes, orpropofol; subject having contraindications to propofol, opioids, and theirantidotes.

• Medical condition or evidence of increased sedation/general anesthesia risk.

• Management risks of respiratory tract and judged by the investigator to beunsuitable for inclusion in the study.

• Any medication that has the potential to interact synergistically with propofol orHSK3486, including but not limited to all sedatives and hypnotics.

• Laboratory parameters significantly out of range at screening.

• Female subjects with a positive pregnancy test (serum or urine) at screening orbaseline; lactating subjects; any subject planning to get pregnant within 1 monthafter the study (including the male subject's partner).

• Judged by the investigator to have any other factors that make the subjectunsuitable for participation in the study.