Phase
Condition
Gastroesophageal Reflux Disease (Gerd)
Esophageal Disorders
Heartburn (Pediatric)
Treatment
upper digestive endoscopy
ARMA (antireflux ablation of the cardiac mucosa)
Clinical Study ID
Ages 18-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age over 18 years.
GERD symptoms lasting more than 6 months, not necessarily consecutive. They shouldat least have a typical GERD symptom (heartburn or regurgitation).
Total acid exposure time> 6% in pH measurement study without PPI treatment.
Patients who do not want to take PPIs or with chronic consumption, defined as PPIconsumption of more than 6 months (consecutive or not) in the last 2 years.
Response to PPI treatment, defined as an increase of> 10 points on the GERD-HRQLquestionnaire 15 days after discontinuation of the PPI.
Written informed consent to participate in the study.
Exclusion
Exclusion Criteria:
Patients with sliding hiatal hernia> 2 cm.
Presence of only atypical GERD symptoms.
Age> 75 years.
Grade D peptic esophagitis.
Body mass index> 35 40 kg / m2.
Liver cirrhosis.
Pregnancy.
Incomplete relaxation of the LES in MAR (PIR> 15 mmHg).
Absent peristalsis, defined as 100% failed waves with DCI <100 mmHg * cm * s in MAR.
Esophagogastric surgery or previous endoscopic antireflux technique.
Barrett's esophagus with dysplasia.
Oncological disease.
Esophageal strictures or ulcers.
Severe cardiopulmonary comorbidity (ASA functional class IV-V).
Previously known coagulopathy.
Severe psychiatric disorder
Refusal to participate in the study.
Study Design
Study Description
Connect with a study center
Hospital de San Agustín
Avilés,
SpainSite Not Available
Hospital Germans Trias I Pujol
Badalona,
SpainSite Not Available
Hospital Del Mar
Barcelona,
SpainSite Not Available
Hospital de Cabueñes
Gijón,
SpainSite Not Available
Hospital 12 de Octubre
Madrid,
SpainSite Not Available
Hospital La Paz
Madrid,
SpainSite Not Available
Complejo Hospitalario de Navarra
Pamplona,
SpainSite Not Available
Hospital de Salamanca
Salamanca,
SpainSite Not Available
Hospital La Fe
Valencia,
SpainSite Not Available
Hospital Rio Hortega
Valladolid,
SpainSite Not Available
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