Defining the Potency of DTG/3TC for Suppressed HIV Patients in Real-life: the DUALING Study

Last updated: December 12, 2024
Sponsor: Erasmus Medical Center
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Hiv

Treatment

Dolutegravir / Lamivudine Pill

Clinical Study ID

NCT04707326
DUALING
  • Ages > 18
  • All Genders

Study Summary

This study aims to determine real-life clinical efficacy of virally suppressed patienst switching to DTG/3TC compared to DTG triple drug cART controls

Eligibility Criteria

Inclusion

Inclusion Criteria:

Plasma HIVRNA <50c/mL on triple drug cART regimen including 2NRTI In care in a HIV treatment center in the Netherlands Consented to ATHENA participation

Exclusion

Exclusion Criteria:

Documented mutations associated with 3TC or DTG resistance of at least low level Documented inadherence by the treating physician or HepB coinfection (cases only)

Study Design

Total Participants: 2040
Treatment Group(s): 1
Primary Treatment: Dolutegravir / Lamivudine Pill
Phase:
Study Start date:
November 01, 2019
Estimated Completion Date:
November 01, 2026

Study Description

Dolutegravir (DTG) based dual antiretroviral therapy constitutes a paradigm shift from triple drug based therapy. Data outside clinical trials are scarce. This study evaluates the value of DTG/3TC in real life.

Connect with a study center

  • Rijnstate Hospital

    Arnhem,
    Netherlands

    Site Not Available

  • Catharina Ziekenhuis

    Eindhoven,
    Netherlands

    Site Not Available

  • Medisch Spectrum Twente

    Enschede,
    Netherlands

    Site Not Available

  • Admiraal de Ruyter Ziekenhuis

    Goes,
    Netherlands

    Site Not Available

  • Spaarne Gasthuis

    Haarlem,
    Netherlands

    Site Not Available

  • Erasmus MC

    Rotterdam, 3015 CN
    Netherlands

    Site Not Available

  • MC Haaglanden

    Rotterdam, 3015 CN
    Netherlands

    Site Not Available

  • Maasstad Hospital

    Rotterdam,
    Netherlands

    Site Not Available

  • Elisabeth Tweesteden Hospital

    Tilburg,
    Netherlands

    Site Not Available

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