3DUS Imaging of Needles in Gynecological Brachytherapy

Last updated: April 9, 2025
Sponsor: Western University, Canada
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vaginal Cancer

Pelvic Cancer

Treatment

Gynecological brachytherapy

Clinical Study ID

NCT04705467
10812
  • Ages > 18
  • Female

Study Summary

Brachytherapy treatment in gynecological cancers is an essential component to delivering adequate doses of radiation to a tumour while sparing normal tissue. Interstitial or intra-cavitary brachytherapy are often needed in advanced or recurrent disease, in cases where intrauterine brachytherapy may not deliver the optimal outcome. Interstitial or intra-cavitary brachytherapy are based on a defined template-and-needle system, and the procedure relies on clinical examination and pre-treatment imaging to guide needle insertion. There is currently no standard image-guided process to help direct needles in the pelvis. We propose using 3D ultrasound to provide real-time imaging for the brachytherapy procedure, which will aid in avoiding needle insertion into pelvic organs and result in optimal dose coverage to the tumour.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Females of age eighteen (18) or greater.

  • Patients with locally advanced or recurrent gynecological malignancies who areoffered interstitial or ring and tandem brachytherapy treatment. These typicallywould include patients with primary or recurrent vaginal cancers, endometrialcancers or cervical cancers. Histologies of these cancers are typicallyadenocarcinomas or squamous cell carcinomas

Exclusion

Exclusion Criteria:

• Above patients who are not offered interstitial brachytherapy as a treatment modality

Study Design

Total Participants: 35
Treatment Group(s): 1
Primary Treatment: Gynecological brachytherapy
Phase:
Study Start date:
October 15, 2022
Estimated Completion Date:
June 30, 2026

Connect with a study center

  • London Regional Cancer Program, Victoria Hospital

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.