Phase
Condition
Vaginal Cancer
Pelvic Cancer
Uterine Disorders
Treatment
Ociperlimab
Ociperlimab
Tislelizumab
Clinical Study ID
Ages > 18 Female
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Histologically or cytologically confirmed squamous cell carcinoma, adenosquamouscarcinoma, or adenocarcinoma of the cervix.
Progression on or after one or more lines of chemotherapy for management ofrecurrent or metastatic disease and is not amenable to curative treatment (eg,systemic chemotherapy, surgery, or radiotherapy).
Measurable disease as assessed by RECIST v1.1. Note: A lesion in an area subjectedto prior loco-regional therapy, including previous radiotherapy, is not consideredmeasurable unless there has been demonstrated progression in the lesion since thetherapy as defined by RECIST v1.1.
Participants must submit qualified archival tumor tissue (formalin-fixedparaffin-embedded block containing tumor [preferred] or approximately 15 [at least 6] unstained slides) with an associated pathology report, or agree to a tumor biopsyfor determination of Programmed death-ligand 1 (PD-L1) expression and otherbiomarker analyses (fresh tumor biopsies are strongly recommended at baseline inparticipants with readily accessible tumor lesions and who consent to the biopsies).
Participant must have adequate organ function as indicated by the screeninglaboratory values obtained within 7 days before the first study treatment.
Exclusion
Exclusion Criteria:
Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, TIGIT or any other antibodyor drug specifically targeting T-cell costimulation or checkpoint pathways.
Any active malignancy ≤ 2 years before first dose of study drug except for thespecific cancer under investigation in this study and any locally recurring cancerthat has been treated curatively (eg, resected basal or squamous cell skin cancer,superficial bladder cancer, carcinoma in situ of breast).
Uncontrollable pleural effusion, pericardial effusion, or ascites requiring frequentdrainage (recurrence within 2 weeks of intervention).
Any major surgical procedure ≤ 28 days before first dose of study drug. Participantsmust have recovered adequately from the toxicity and/or complications from theintervention before the first dose of study drug.
Has received any chemotherapy, immunotherapy (eg, interleukin, interferon, thymosin,etc.) or any investigational therapies within 14 days or 5 half-lives (whichever islonger) before the first dose of study drug or has received palliative radiationtreatment or other local regional therapies within 14 days before the first dose ofstudy drug.
Note: Other protocol defined Inclusion/Exclusion criteria may apply
Study Design
Connect with a study center
"Mhat uni hospital" ood
Panagyurishte, 4500
BulgariaSite Not Available
Complex Oncology Center Rousse Eood
Ruse, 7002
BulgariaSite Not Available
Acibadem city clinic tokuda umhat ead, department of medical oncology
Sofia, 1407
BulgariaSite Not Available
Medical center nadezhda clinical eood
Sofia, 13330
BulgariaSite Not Available
Anhui Provincial Cancer Hospital
Hefei, Anhui 230088
ChinaSite Not Available
Chongqing Cancer Hospital
Chongqing, Chongqing 400030
ChinaSite Not Available
Southwest Hospital
Chongqing, Chongqing 400038
ChinaSite Not Available
Gansu Provincial Hospital
Lanzhou, Gansu 730000
ChinaSite Not Available
Sun yat-sen memorial hospital, sun yat-sen university (south)
Guanzhou, Guangdong 510275
ChinaSite Not Available
The Tumor Hospital Affiliated to Guangxi Medical University
Nanning, Guangxi 530021
ChinaSite Not Available
Hainan Cancer Hospital
Haikou, Hainan 570312
ChinaSite Not Available
Henan Cancer Hospital - Oncology
Zhengzhou, Henan 450008
ChinaSite Not Available
Hubei Cancer Hospital - Oncology
Wuhan, Hubei 400037
ChinaSite Not Available
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei 430022
ChinaSite Not Available
Hunan Cancer Hospital - GCP Office
Changsha, Hunan 410013
ChinaSite Not Available
Xuzhou Cancer Hospital
Xuzhou, Jiangsu 221005
ChinaSite Not Available
The First Affiliated Hospital of Nanchang University Branch Donghu
Nanchang, Jiangxi 330006
ChinaSite Not Available
Jilin Guowen Hospital
Jilin, Jilin 136100
ChinaSite Not Available
Liaoning Cancer Hospital & Institute - Medical Oncology - Oncology
Shenyang, Liaoning 110017
ChinaSite Not Available
General Hospital of Ningxia Medical University
Yinchuan, Ningxia 750004
ChinaSite Not Available
Qilu Hospital of Shandong University
Jinan, Shandong 250012
ChinaSite Not Available
Obstetrics and Gynecology Hospital of Fudan University
Shanghai, Shanghai
ChinaSite Not Available
Second Hospital Of Shanxi Medical University
Taiyuan, Shanxi 030013
ChinaSite Not Available
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shanxi 710000
ChinaSite Not Available
Tianjin Medical University Cancer institute & Hospital
Tianjin, Tianjin 300070
ChinaSite Not Available
Affiliated Cancer Hospital of Xinjiang Medical University
Urumqi, Xinjiang 830000
ChinaSite Not Available
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang 310003
ChinaSite Not Available
Zhejiang Cancer Hospital
Hangzhou, Zhejiang 310022
ChinaSite Not Available
Beijing Cancer Hosptial
Beijing,
ChinaSite Not Available
Cancer Hospital Chinese Academy of Medical Sciences
Beijing,
ChinaSite Not Available
Linyi Cancer Hospital
Shandong, 276002
ChinaSite Not Available
The First Affiliated Hospital of Xiamen University - Oncology
Xiamen, 361005
ChinaSite Not Available
Keimyung University Dongsan Medical Center
Daegu, 42601
Korea, Republic ofSite Not Available
Kyemyung University Dongsan Hospital
Daegu,
Korea, Republic ofSite Not Available
Ajou University Hospital
Gyeonggi-do,
Korea, Republic ofSite Not Available
National Cancer Center
Gyeonggi-do,
Korea, Republic ofSite Not Available
Seoul National University Bundang Hospital
Gyeonggi-do,
Korea, Republic ofSite Not Available
Asan Medical Center
Seoul,
Korea, Republic ofSite Not Available
Gangnam Severance Hospital
Seoul,
Korea, Republic ofSite Not Available
Korea Institute of Radiological & Medical Sciences
Seoul,
Korea, Republic ofSite Not Available
Korea University Guro Hospital
Seoul,
Korea, Republic ofSite Not Available
Samsung Medical Center
Seoul,
Korea, Republic ofSite Not Available
Seoul National University Hospital
Seoul,
Korea, Republic ofSite Not Available
Severance Hospital, Yonsei University Health System
Seoul,
Korea, Republic ofSite Not Available
Szpitale Pomorskie Spółka z ograniczoną odpowiedzialnością
Gdynia,
PolandSite Not Available
Przychodnia lekarska komed
Konin, 62-500
PolandSite Not Available
State healthcare institution oncologic dispensary no. 2 - health department of krasnodar region
Krasnodar, Krasnodar Krai 350015
Russian FederationSite Not Available
Fsbi of higher education"ogarev mordovia state university"
Saransk, Mordovia Republic 430005
Russian FederationSite Not Available
Oncological Scientific Center LLC
Pesochny, Saint Petersburg 197758
Russian FederationSite Not Available
Sbhi of stavropol region "pyatigorsk interdistrict oncologic dispensary"
Pyatigorsk, Stavropol Region
Russian FederationSite Not Available
Arkhangelsk regional clinical oncological dispensary
Arkhangel'sk,
Russian FederationSite Not Available
State budgetary healthcare institution-chelyabinsk regional clinical center of oncology and nuclear
Chelyabinsk, 454087
Russian FederationSite Not Available
Chi Mei Hospital, Liouying
Tainan,
TaiwanSite Not Available
Linkou Chang Gung Memorial Hospital
Tainan,
TaiwanSite Not Available
National Cheng Kung University Hospital
Tainan,
TaiwanSite Not Available
Mackay Memorial Hospital
Taipei,
TaiwanSite Not Available
National Taiwan University Hospital
Taipei,
TaiwanSite Not Available
Taipei Veterans General Hospital
Taipei,
TaiwanSite Not Available
Siriraj Hospital
Bangkok Noi, Bangkok 10700
ThailandSite Not Available
Songklanagarind Hospital, Prince of Songkla University
Hat Yai,
ThailandSite Not Available
Srinagarind Hospital (Khon Kaen University)
Khon Kaen, 40002
ThailandSite Not Available
Phramongkutklao Hospital
Ratchathewi, 10400
ThailandSite Not Available
Public Non-Profit Institution "Precarpathian Oncology Center Of Ivano-Frankivsk Regional Council"
Ivano-Frankivsk Oblast, Ivano-Frankivsk 00000
UkraineSite Not Available
Medical and diagnostic center of private enterprise private production company "acinus"
Kirovograd, Kirovohradska Oblast 25006
UkraineSite Not Available
Communal Non-Profit Enterprise Of Sumy Regional Council Sumy Regional Clinical Oncological Dispensar
Sumy, Sumska Oblast 40022
UkraineSite Not Available
National Cancer Institute
Kiev, 3022
UkraineSite Not Available
Medical center of llc oncolife
Kropyvnytskyi, 25006
UkraineSite Not Available
Volyn Regional Medical Center Of Oncology
Luts'k, 03322
UkraineSite Not Available

Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.