Cerebrospinal Fluid Biomarkers for Brain Tumors

Inclusion Criteria:

• Any evidence of neoplasm involving the central nervous system (CNS) or its adjacentstructures in contact with CSF. Such lesions may include but are not limited tointra-axial or extra-axial lesions, which could be benign, malignant or as yetundefined, involving the brain, spine, meninges, nerves, or vasculature orsupporting structures

• Subjects must be 18 years of age or older

Exclusion Criteria:

• Patients who are under 18 years of age or are a member of a vulnerable populationwill be excluded from this study

• Pregnant women or women who may be pregnant are specifically excluded from studyparticipation

• Exception will be granted for patients with diminished capacity to consent if alegally authorized representative is available

• Patients without clinical or radiographic evidence of a potentially neoplastic CNSlesion will be excluded

• Patients with an inability or unwillingness of individual or legalguardian/representative to give written informed consent will be excluded

• Any patient for whom a clinical contraindication exists to the intended route of CSFaccess will be excluded. For example, a patient with a large posterior fossa masslesion at risk of herniation, or a patient with coagulopathy, or othercontraindication to lumbar puncture would not be eligible to participate via use oflumbar puncture for CSF access