New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis

Last updated: July 19, 2023
Sponsor: Assistance Publique Hopitaux De Marseille
Overall Status: Active - Recruiting

Phase

N/A

Condition

Amyotrophic Lateral Sclerosis (Als)

Scar Tissue

Myasthenia Gravis (Chronic Weakness)

Treatment

Spinal cord MRI

Electrophysiological exam

Muscular MRI

Clinical Study ID

NCT04691011
2020-50
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression. Our project aims to find new biomarkers in MRI at three levels: cerebral, medullary and muscular. These markers could allow an earlier diagnosis of the disease by showing more specific lesions of ALS and to quantify these lesions to measure the progression of the disease. This study will use advanced Magnetic Resonance Imaging (MRI) techniques High field (3T) and very high field (7T) MRI. Results from neurological and electrophysiological tests will be compared to the MRI. Subjects will be recruited from ALS center of Marseille, France. MRI will be done on ALS patients at baseline, at 3 month and at 6 month intervals.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients will be adults with a diagnosis of ALS.
  • Healthy controls will also be recruited and will be age- and gender-matched topatients.
  • Patients able to undergo a brain MRI for approximately an hour.

Exclusion

Exclusion Criteria:

  • Subjects with other psychiatric or CNS or PNS diseases.
  • Subjects ineligible for MRI investigation due to a pacemaker or other metallic foreignbody, or significant claustrophobia that could affect the ability to have an MRI scan.

Study Design

Total Participants: 160
Treatment Group(s): 4
Primary Treatment: Spinal cord MRI
Phase:
Study Start date:
June 16, 2021
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Shahram Attarian

    Marseille, 13005
    France

    Active - Recruiting

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