Sonazoid-enhanced Ultrasound for the Detection of Colorectal Liver Metastases Less Than 2 cm

Last updated: December 27, 2020
Sponsor: Sun Yat-sen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Liver Cancer

Digestive System Neoplasms

Primary Biliary Cholangitis

Treatment

N/A

Clinical Study ID

NCT04686942
Sonazoid001
  • Ages 18-85
  • All Genders

Study Summary

Preoperative chemotherapy is often used for patients with colorectal cancer liver metastasis (CLM). Many small CLMs (<=2cm) may disappear after chemotherapy, while most of these are still alive. Ultrasonography (US) is a common imaging modality for the intraoperative detection tumor. Sonazoid is new echo-contrast agent, which is more stable and sensitive for detecting of small tumor. Investigators initially this prospective study to compare the detection performance before and after using sonazoid.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pathology confirmed colorectal adenocarcinoma
  • One or more liver metastases less than 2 cm
  • Multidisciplinary team recommend to perform preoperative chemotherapy
  • Have baseline EOB-MR before chemotherapy

Exclusion

Exclusion Criteria:

  • Could not fulfill the criteria of no evidence of disease (NED) after hepaticresection/ablation/radiotherapy
  • With other malignancies

Study Design

Total Participants: 550
Study Start date:
December 17, 2020
Estimated Completion Date:
December 30, 2023

Connect with a study center

  • Sun Yat-sen University Cancer Center

    Guangzhou,
    China

    Active - Recruiting

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