Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF

Inclusion Criteria:

• Age:18-38 years old

• Diagnosis of PCOS according to compliance with the Rotterdam criteria

• BMI >= 25

Exclusion Criteria:

• Hormonal contraceptive, insulin sensitizers such as metformin, inositols,antioxidants, vitamin supplements except folic acid, GnRH analogs, steroidal drugsor others with anti-inflammatory properties, antibiotics, probiotics, laxatives usein the 3 months prior to recruitment

• Tobacco consumption in last 12 months

• Endometriosis, hydrosalpinx not surgically treated, acute or chronic inflammatorydiseases, systemic immune diseases, other endocrine diseases or dysfunctions exceptfor PCOS and subclinical hypothyroidism treated with low doses of levothyroxine (egcongenital adrenal hyperplasia, Cushing's syndrome, androgen-secreting tumors,Diabetes Millitus, hyperprolactinemia, hyperglycemia), active neoplastic disease orwithout evidence of complete remission for at least 5 years,

• Active participation in an active weight reduction program or hypocaloric dietduring the study period. No change in habits will be taught during the study period

• Hypersensitivity to any of the components in the Fertybiotic Mujer Plus® formulation