Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

Last updated: July 26, 2024
Sponsor: Icahn School of Medicine at Mount Sinai
Overall Status: Active - Recruiting

Phase

N/A

Condition

Alzheimer's Disease

Mild Cognitive Impairment

Dementia

Treatment

Individualized Music Therapy (IMT)

Home-based MT through Supervised, Supported Singing (H3S)

Attention Control (AtCon)

Clinical Study ID

NCT04666077
GCO 19-0243(0002)
  • Ages > 55
  • All Genders

Study Summary

This study compares different music therapy (MT) experiences and their impact on memory and language in patients with Alzheimer's disease and Mild Cognitive Impairment.

The 12-month study will assess the role of common experiences involving familiar music and other pleasant events (blinded control) to benefit cognition and measure the quality of life for people with Alzheimer's disease and Mild Cognitive Impairment.

Following screening, all participants will meet with a licensed music therapist at the first study visit. Thereafter, each group will have an individualized schedule of follow-up telephone calls and visits.

Screening for the study and participation in the study intervention can be completed in-person or from your home, if you do not live in the area.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of Alzheimer's disease or mild cognitive impairment

  • Must have study partner

  • English speaking

  • No verbal impairment

  • Community-dwelling

  • Must have webcam or smart phone

Exclusion

Exclusion Criteria:

  • A diagnosis of dementia other than probable or possible AD

  • Probable AD with Down syndrome

  • History of a clinically significant stroke with residual deficit

  • Current evidence or history in past two years of epilepsy, focal brain lesion, headinjury

  • Current diagnosis for major psychiatric disorder including psychosis, majordepression, bipolar disorder, alcohol or substance abuse.

  • Participation in another interventional study

  • Comorbidity causing disability interfering with intervention such as pain ordiscomfort or life expectancy less than 1 year

Study Design

Total Participants: 100
Treatment Group(s): 3
Primary Treatment: Individualized Music Therapy (IMT)
Phase:
Study Start date:
August 27, 2019
Estimated Completion Date:
July 31, 2025

Study Description

Interested participants and their study partner will be enrolled after an evaluation to determine cognitive impairment or mild dementia. The evaluation, either in person or remote, will include cognitive testing, clinical and neurological evaluation, a review medical records and medical history and an examination as deemed necessary by a dementia physician. Eligible participants will undergo baseline testing including linguistic analyses and will be randomly assigned to one of 3 intervention groups. Participants and their study partners will be contacted at least once every three months for cognitive testing and medical review. Contact with the music therapy team will occur up to twice per week but not less than once per month, for the first six months study enrollment.

Connect with a study center

  • Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai

    New York, New York 10029
    United States

    Active - Recruiting

  • Louis Armstrong Center for Music and Medicine, Mount Sinai Beth Israel

    New York, New York 10003
    United States

    Active - Recruiting

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