IMMunological ResPonse Assessment AfteR Acute ISchemic Stroke Treated with Endovascular Therapy (IMPRESS)

Last updated: March 20, 2025
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Cardiac Ischemia

Cerebral Ischemia

Treatment

Prospective patient

Clinical Study ID

NCT04663399
BMR_2020_32
  • Ages > 18
  • All Genders

Study Summary

IMPRESS study aims to describe the immuno-inflammatory and thrombo-inflammatory profiles during the first 24/36 hours of treatment of patients suffering from AIC treated with TM, and to study the possible impact of these profiles on the functional prognosis at 3 months of AIC treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient with an acute ischemic stroke for which treatment with mechanicalthrombectomy is indicated, whether or not thrombectomy is performed,

  • Having received informed information about the study and having signed a consent toparticipate in the study (if this is not possible: information and consent of thetrusted support person or family member if present; emergency inclusion if absent);

  • Affiliated or beneficiary of a social security scheme or equivalent.

Non inclusion Criteria:

  • Pregnant or breast-feeding women

  • Patient benefiting from a legal protection measure

Exclusion

Exclusion Criteria:

None.

Study Design

Total Participants: 400
Treatment Group(s): 1
Primary Treatment: Prospective patient
Phase:
Study Start date:
February 23, 2023
Estimated Completion Date:
May 23, 2028

Study Description

Stroke is the second leading cause of death worldwide, the leading cause of acquired disability and the second leading cause of dementia. Ischaemic strokes account for 80% of strokes, 40% of which are caused by occlusion of a large-calibre artery in the polygon of Willis. In 2020, the treatment focuses on recanalisation, as quickly as possible. This is achieved medically by intravenous thrombolysis (IVT) and, since 2015, by mechanical thrombectomy (MT) in cases of proximal anterior artery occlusion. Thrombectomy has revolutionised the management of AIC, as it results in over 90% recanalisation at the end of treatment. However, more than half of patients managed between 3 and 6 hours, and recanalised with TM, remain dependent at 3 months.

In recent years, numerous studies (mainly preclinical) have highlighted the impact of the systemic and cerebral inflammatory reaction following AIC. Interestingly, this immuno-inflammatory reaction seems to follow a precise chronology and involves various immune players. Several preclinical studies in rodents have shown that this immunoinflammatory response appears to be strongly associated with prognosis (final stroke volume, disability and post-stroke dementia).

The absence of reliable biomarkers in humans to better describe and assess the chronology of the immuno-inflammatory profile after stroke appears to be a fundamental limitation to the introduction of innovative treatments. These biomarkers would make it possible to select and accurately assess the time required to introduce treatments such as immunomodulatory therapies (Natalizumab, Fingolimod, Copaxone, cell therapy, etc.). New studies seem necessary to identify peripheral biomarkers of the immuno-inflammatory state (cytokines, precise cell typing), and of thrombo-inflammation (NETose markers, neutrophil markers) and their consequences on disability after an ACI.

The aim of the IMPRESS study is therefore to describe the immuno-inflammatory and thrombo-inflammatory profiles during the first 24 +/-12 hours of the management of patients suffering from AIC treated with TM, and to study the possible impact of these profiles on the functional prognosis 3 months after the AIC has been managed.

Connect with a study center

  • Hôpital Fondation Adolphe de Rothschild

    Paris, 75019
    France

    Active - Recruiting

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