Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Inclusion Criteria:

1. History of migraine (with or without aura) for > 6 months before Screening accordingto the IHS Classification ICHD-319 specifications for pediatric migraine. Historymay be verified using both medical records and recall by the participant and/orparticipant's parent(s)/legal representative(s).

2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior toenrollment, with attacks lasting > 3 hours without treatment, and attacks occurringat intervals > 24 hours.

3. Prophylactic migraine medication are permitted if the dose has been stable for atleast 12 weeks prior to the Baseline Visit, and the dose is not expected to changeduring the course of the study.

4. Participants may remain on one (1) medication with possible migraineprophylactic effects, excluding CGRP antagonists [biologic or small molecule],during the treatment phases.

5. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, isprohibited.

6. Previously discontinued prophylactic migraine medication must have done so atleast 90 days prior to the Screening Visit.

7. Verbally distinguish between migraine and other types of headaches.

8. Participants must have a weight > 40 kg at the Screening Visit.

9. Adequate venous access for blood sampling.

10. Male and female participants ≥ 6 to < 18 years of age (participants must not reachtheir 18th birthday during the study).

Exclusion Criteria:

1. History of cluster headache or hemiplegic migraine headache.

2. Confounding and clinically significant pain syndrome that may interfere with theparticipant's ability to participate in this study.

3. Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history ofpsychosis and/or mania.

4. History of suicidal behavior or major psychiatric disorder.

5. Current diagnosis or history of substance abuse; positive drug test at Screening.

6. History of moderate or severe head trauma or other neurological disorder (includingseizure disorder) or systemic medical disease that is likely to affect centralnervous system functioning.

7. Recent or planned surgery, requiring general anesthesia, <8 weeks prior to theScreening Visit.

8. Participant has had gastrointestinal surgery that interferes with physiologicalabsorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).

9. Current diagnosis of viral hepatitis or a history of liver disease.

10. Conditions considered clinically relevant in the context of the study such asuncontrolled hypertension (high blood pressure), diabetes, a life-threateningallergy