A Clinical Trial About the Safety of Surgical Treatment in Severe Primary Pontine Hemorrhage

Inclusion Criteria:

1. Clinical diagnosis of PPH: patients have acute hemorrhage mainly in pons with adefinite history of hypertension.
2. GCS 5~7 and HV≥5ml on admission (the HV in intraventricular system being excluded).
3. Family members consenting to randomize and signing informed consent form (ICF).
4. Time from onset to admission less than 24 hours.
5. Age:18 years or older.

Exclusion Criteria:

1. Structural lesions such as brainstem cavernous malformation, arteriovenousmalformation, aneurysm, tumor apoplexy.
2. GCS≥8 and HV<5ml.
3. Time from onset to admission over 24 hours.
4. Patients with platelet count < 100,000, International Normalized Ratio (INR)> 1.4, oran elevated prothrombin time (PT) and activated partial thromboplastin time (APTT).
5. Multiple ICH.
6. Accompanying hydrocephalus that requires surgical management
7. Irreversible brainstem failure (bilateral fixed, dilated pupils and extensor motorposturing, GCS≤4).
8. A previous history of ICH.
9. Any serious concurrent illness that would interfere with the safety assessmentsincluding hepatic, renal, gastroenterologic, respiratory, cardiovascular,endocrinologic, immunologic, and hematologic disease.
10. Pregnant patients.
11. Patients' family members refuse HE.
12. Any other condition that the investigator believes would present a significant hazardto the subject if the investigational therapy were initiated.
13. Participating in another simultaneous trial of ICH treatment.