Magnetic Resonance Imaging Study on Patients With Hemifacial Spasm

Last updated: February 22, 2024
Sponsor: First Affiliated Hospital Xi'an Jiaotong University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pain (Pediatric)

Hemifacial Spasm

Treatment

Scanning with magnetic resonance imaging

Clinical Study ID

NCT04645277
XJTU1AF-CRF-2020-017
  • Ages 20-60
  • All Genders

Study Summary

Up to now, multiplanar reconstruction (MPR) has been widely used to detect the neurovascular compressions (NVC) on the patients with hemifacial spasm (HFS). However, due to lack of stereoscopic vision, this traditional method sometimes can not meet the requirement on identifying the details of NVC, especially when the aberrant vessels turn out to be veins not arteries. The three dimensional analytic techniques, such as curved planar reconstruction (CPR) and magnetic resonance virtual endoscopy (MRVE), may be helpful to improve the sensitivity and specificity on the demonstration of NVC with stereo and dynamic views, so as to assist the design of the surgical plan.

Furthermore, the frequent finding of NVC on MRI studies of asymptomatic patients incited the creation of several strict criteria for the imaging diagnosis of NVC: the vessel must cross perpendicular to the long axis of the nerve, the nerve must be deviated or indented at the root entry zoon (REZ) by the vessel. Alternatively, morphological measurement of the nerve may correlate with the severity of facial spasm due to atrophy of the nerve in most cases of HFS, and is likely secondary to the micro-structural abnormalities, such as axonal loss, demyelination, collagen deposition, etc. In this study, cross-sectional area (CSA) and volume (V) of the cisternal facial nerve will be assessed to determine whether it can be a useful biomarker for predicting the degree of HFS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Primary HFS patients according to medical history and typical facial muscle spasmsthat are unilateral, involuntary, and had intermittent contractions innervated by theipsilateral facial nerve. The patient has 1 year disease duration at least.

Exclusion

Exclusion Criteria:

  • Secondary causes of HFS, such as tumors or cysts compressing the facial nerve in thecerebellar pontine cistern; Precarious general health status; Percutaneous lesions orsurgical treatments; Cardiac pacemaker or metal implants.

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Scanning with magnetic resonance imaging
Phase:
Study Start date:
January 01, 2021
Estimated Completion Date:
December 30, 2024

Connect with a study center

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi 710061
    China

    Active - Recruiting

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