Open-label Extension Study for CLCZ696G2301 (PARADISE-MI)

Inclusion Criteria:

1. Written informed consent must be obtained before any assessment is performed.
2. Participant received study treatment (either in LCZ696 or ramipril treatment arm) inPARADISE-MI.
3. Participant is safe to be enrolled in the extension study and may benefit from thetreatment of LCZ696 per investigator's clinical judgement.

Exclusion Criteria:

1. Participant with a known history of angioedema
2. History of hypersensitivity to the study drug or drugs of similar chemical classes orknown intolerance or contraindications to study drug or drugs of similar chemicalclasses including ACE inhibitors, ARB or NEP inhibitors
3. Symptomatic hypotension at screening
4. Serum potassium > 5.2 mmol /L (or equivalent plasma potassium value) at screening
5. Known hepatic impairment (as evidenced by total bilirubin > 3.0 mg/dL or increasedammonia levels, if performed), or history of cirrhosis with evidence of portalhypertension such as esophageal varices
6. Pregnant or nursing women or women of child-bearing potential unless they are usinghighly effective methods of contraception
7. Other protocol-defined inclusion/exclusion criteria may apply