MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Last updated: September 4, 2025
Sponsor: Nicox Ophthalmics, Inc.
Overall Status: Completed

Phase

3

Condition

Open Angle Glaucoma

Circulation Disorders

Vascular Diseases

Treatment

Latanoprost 0.005%

NCX 470 0.1%

Clinical Study ID

NCT04630808
NCX-470-03
  • Ages 18-84
  • All Genders

Study Summary

The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of open-angle glaucoma or ocular hypertension in both eyes

  • Qualifying IOP at 3 time points through the day at 2 visits following washout ofIOP-lowering medication, if applicable

  • Qualifying best-corrected visual acuity in each eye

  • Ability to provide informed consent and follow study instructions

Exclusion

Exclusion Criteria:

  • Narrow anterior chamber angles or disqualifying corneal thickness in either eye

  • Clinically significant ocular disease in either eye

  • Previous complicated surgery or certain types of glaucoma surgery in either eye

  • Incisional ocular surgery or severe trauma in either eye within the past 6 months

  • Uncontrolled systemic disease

Study Design

Total Participants: 696
Treatment Group(s): 2
Primary Treatment: Latanoprost 0.005%
Phase: 3
Study Start date:
November 09, 2020
Estimated Completion Date:
June 25, 2025

Connect with a study center

  • Nicox Clinical Site

    Lanzhou, Gansu 730030
    China

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  • Nicox Clinical Site

    Lanzhou 1804430, Gansu 1810676 730030
    China

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  • Nicox Clinical Site

    Shantou, Guangdong 515401
    China

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  • Nicox Clinical Site

    Shantou 1795940, Guangdong 1809935 515401
    China

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  • Nicox Clinical Site

    Harbin, Heilongjiang 150086
    China

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  • Nicox Clinical Site

    Harbin 2037013, Heilongjiang 2036965 150086
    China

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  • Nicox Clinical Site

    Zhengzhou, Henan 450052
    China

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  • Nicox Clinical Site

    Zhengzhou 1784658, Henan 1808520 450052
    China

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  • Nicox Clinical Site

    Wuhan, Hubei 430060
    China

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  • Nicox Clinical Site

    Yichang, Hubei 443003
    China

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  • Nicox Clinical Site

    Wuhan 1791247, Hubei 1806949 430060
    China

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  • Nicox Clinical Site

    Yichang 1786764, Hubei 1806949 443003
    China

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  • Nicox Clinical Site

    Changsha 1815577, Huna 410015
    China

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  • Nicox Clinical Site

    Changsha, Hunan 410011
    China

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    Nanchang, Jiangxi 330006
    China

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    Nanchang 1800163, Jiangxi 1806222 330006
    China

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    Changchun, Jilin 130021
    China

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    Changchun 2038180, Jilin 2036500 130021
    China

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    Dalian, Liaoning 116091
    China

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    Dalian 1814087, Liaoning 2036115 116091
    China

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    Xi'an, Shaanxi 710004
    China

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    Xi'an 1790630, Shaanxi 1796480 710004
    China

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    Jinan, Shandong 250002
    China

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    Qingdao, Shandong 266071
    China

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    Jinan 1805753, Shandong 1796328 250002
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    Qingdao 1797929, Shandong 1796328 266071
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    Chengdu, Sichuan 610041
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    Chengdu 1815286, Sichuan 1794299 610041
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    Wenzhou, Xhejiang 325027
    China

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    Wenzhou 1791388, Xhejiang 325027
    China

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    Beijing, 100191
    China

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    Beijing 1816670, 100005
    China

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    Chongqing, 400020
    China

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    Chongqing 1814906, 400020
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    Shanghai, 200040
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    Shanghai 1796236, 200011
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    Tianjing, 300384
    China

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    Tianjing 9613729, 300020
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    Dothan, Alabama 36301
    United States

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    Dothan 4059102, Alabama 4829764 36301
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    Chandler, Arizona 85224
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    Phoenix, Arizona 85003
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    Chandler 5289282, Arizona 5551752 85224
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    Phoenix 5308655, Arizona 5551752 85003
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    Burbank, California 91505
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    Garden Grove, California 92843
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    Huntington Beach, California 92647
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    La Jolla, California 92037
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    Murrieta, California 92562
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    Newport Beach, California 92663
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    Mount Dora, Florida 32757
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    Jacksonville 4160021, Florida 4155751 32256
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    Jupiter 4160610, Florida 4155751 33477
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    Largo 4161580, Florida 4155751 33770
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    Mt. Dora 4165069, Florida 4155751 32757
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    Morrow, Georgia 30260
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    Roswell, Georgia 30076
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    Morrow 4210254, Georgia 4197000 30260
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    Rock Island, Illinois 61201
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    Peoria 4905687, Illinois 4896861 61615
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    Rock Island 4907907, Illinois 4896861 61201
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    Indianapolis, Indiana 46202
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    Indianapolis 4259418, Indiana 4921868 46202
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    Bangor, Maine 04401
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    Bangor 4957280, Maine 4971068 04401
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    Boston, Massachusetts 02114
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    Lancaster, Massachusetts 01523
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    Boston 4930956, Massachusetts 6254926 02114
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    Lancaster 4941635, Massachusetts 6254926 01523
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    Grand Rapids, Michigan 49546
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    Grand Rapids 4994358, Michigan 5001836 49546
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    Chaska, Minnesota 55318
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    Chaska 5020938, Minnesota 5037779 55318
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    Kansas City, Missouri 64111
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    Saint Louis, Missouri 63128
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    Kansas City 4393217, Missouri 4398678 64111
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    St Louis 4407066, Missouri 4398678 63128
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    Bronx, New York 10467
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    Clifton Park, New York 12065
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    Troy, New York 12180
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    Clifton Park 5112961, New York 5128638 12065
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    The Bronx 5110266, New York 5128638 10467
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    Troy 5141502, New York 5128638 12180
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    Asheville, North Carolina 28803
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    Winston-Salem, North Carolina 27101
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    Asheville 4453066, North Carolina 4482348 28803
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    Winston-Salem 4499612, North Carolina 4482348 27101
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    Fargo, North Dakota 58103
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    Fargo 5059163, North Dakota 5690763 58103
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    Cincinnati, Ohio 45242
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    Cincinnati 4508722, Ohio 5165418 45242
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    Eugene, Oregon 97401
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    Eugene 5725846, Oregon 5744337 97401
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    Cranberry Township, Pennsylvania 16066
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    Kingston, Pennsylvania 18704
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    Cranberry Township 8643098, Pennsylvania 6254927 16066
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    Kingston 5196245, Pennsylvania 6254927 18704
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    Memphis, Tennessee 38120
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    Memphis 4641239, Tennessee 4662168 38119
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    Austin, Texas 78731
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    El Paso, Texas 79922
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    Houston, Texas 77008
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    Mission, Texas 78572
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    Sugar Land, Texas 77479
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    Austin 4671654, Texas 4736286 78731
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    El Paso 5520993, Texas 4736286 79922
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    Houston 4699066, Texas 4736286 77008
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    Mission 4711725, Texas 4736286 78572
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    San Antonio 4726206, Texas 4736286 78229
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    Sugar Land 4734825, Texas 4736286 77479
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    Saint George, Utah 84790
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    St. George 5546220, Utah 5549030 84790
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    Falls Church, Virginia 22042
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    Falls Church 4758390, Virginia 6254928 22042
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    Bellevue, Washington 98004
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    Seattle, Washington 98104
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    Bellevue 5786882, Washington 5815135 98004
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  • Nicox Clinical Site

    Seattle 5809844, Washington 5815135 98125
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