MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Last updated: January 7, 2025
Sponsor: Nicox Ophthalmics, Inc.
Overall Status: Active - Not Recruiting

Phase

3

Condition

Vascular Diseases

Open Angle Glaucoma

Circulation Disorders

Treatment

Latanoprost 0.005%

NCX 470 0.1%

Clinical Study ID

NCT04630808
NCX-470-03
  • Ages 18-84
  • All Genders

Study Summary

The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of open-angle glaucoma or ocular hypertension in both eyes

  • Qualifying IOP at 3 time points through the day at 2 visits following washout ofIOP-lowering medication, if applicable

  • Qualifying best-corrected visual acuity in each eye

  • Ability to provide informed consent and follow study instructions

Exclusion

Exclusion Criteria:

  • Narrow anterior chamber angles or disqualifying corneal thickness in either eye

  • Clinically significant ocular disease in either eye

  • Previous complicated surgery or certain types of glaucoma surgery in either eye

  • Incisional ocular surgery or severe trauma in either eye within the past 6 months

  • Uncontrolled systemic disease

Study Design

Total Participants: 696
Treatment Group(s): 2
Primary Treatment: Latanoprost 0.005%
Phase: 3
Study Start date:
November 09, 2020
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • Nicox Clinical Site

    Lanzhou, Gansu 730030
    China

    Site Not Available

  • Nicox Clinical Site

    Shantou, Guangdong 515401
    China

    Site Not Available

  • Nicox Clinical Site

    Harbin, Heilongjiang 150086
    China

    Site Not Available

  • Nicox Clinical Site

    Zhengzhou, Henan 450003
    China

    Site Not Available

  • Nicox Clinical Site

    Wuhan, Hubei 430060
    China

    Site Not Available

  • Nicox Clinical Site

    Yichang, Hubei 443003
    China

    Site Not Available

  • Nicox Clinical Site

    Changsha, Huna 410015
    China

    Site Not Available

  • Nicox Clinical Site

    Nanchang, Jiangxi 330006
    China

    Site Not Available

  • Nicox Clinical Site

    Changchun, Jilin 130021
    China

    Site Not Available

  • Nicox Clinical Site

    Dalian, Liaoning 116091
    China

    Site Not Available

  • Nicox Clinical Site

    Xi'an, Shaanxi 710004
    China

    Site Not Available

  • Nicox Clinical Site

    Jinan, Shandong 250002
    China

    Site Not Available

  • Nicox Clinical Site

    Qingdao, Shandong 266071
    China

    Site Not Available

  • Nicox Clinical Site

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • Nicox Clinical Site

    Wenzhou, Xhejiang 325027
    China

    Site Not Available

  • Nicox Clinical Site

    Beijing, 100191
    China

    Site Not Available

  • Nicox Clinical Site

    Chongqing, 400020
    China

    Site Not Available

  • Nicox Clinical Site

    Shanghai, 200040
    China

    Site Not Available

  • Nicox Clinical Site

    Tianjing, 300020
    China

    Site Not Available

  • Nicox Clinical Site

    Dothan, Alabama 36301
    United States

    Site Not Available

  • Nicox Clinical Site

    Chandler, Arizona 85224
    United States

    Site Not Available

  • Nicox Clinical Site

    Phoenix, Arizona 85003
    United States

    Site Not Available

  • Nicox Clinical Site

    Burbank, California 91505
    United States

    Site Not Available

  • Nicox Clinical Site

    Garden Grove, California 92843
    United States

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  • Nicox Clinical Site

    Huntington Beach, California 92647
    United States

    Site Not Available

  • Nicox Clinical Site

    La Jolla, California 92037
    United States

    Site Not Available

  • Nicox Clinical Site

    Murrieta, California 92562
    United States

    Site Not Available

  • Eye Research Foundation

    Newport Beach, California 92663
    United States

    Active - Recruiting

  • Nicox Clinical Site

    Newport Beach, California 92663
    United States

    Site Not Available

  • Nicox Clinical Site

    Pasadena, California 91107
    United States

    Site Not Available

  • Nicox Clinical Site

    Petaluma, California 94954
    United States

    Site Not Available

  • Nicox Clinical Site

    Redlands, California 92373
    United States

    Site Not Available

  • Nicox Clinical Site

    San Francisco, California 94115
    United States

    Site Not Available

  • Nicox Clinical Site

    Danbury, Connecticut 06810
    United States

    Site Not Available

  • Nicox Clinical Site

    Boynton Beach, Florida 33437
    United States

    Site Not Available

  • Nicox Clinical Site

    Delray Beach, Florida 33484
    United States

    Site Not Available

  • Nicox Clinical Site

    Fort Lauderdale, Florida 33309
    United States

    Site Not Available

  • Nicox Clinical Site

    Fort Myers, Florida 33901
    United States

    Site Not Available

  • Nicox Clinical Site

    Jacksonville, Florida 32256
    United States

    Site Not Available

  • Nicox Clinical Site

    Jupiter, Florida 33477
    United States

    Site Not Available

  • Nicox Clinical Site

    Lakeland, Florida 33805
    United States

    Site Not Available

  • Nicox Clinical Site

    Largo, Florida 33770
    United States

    Site Not Available

  • Nicox Clinical Site

    Mount Dora, Florida 32757
    United States

    Site Not Available

  • Nicox Clinical Site

    Venice, Florida 34285
    United States

    Site Not Available

  • Nicox Clinical Site

    Morrow, Georgia 30260
    United States

    Site Not Available

  • Nicox Clinical Site

    Roswell, Georgia 30076
    United States

    Site Not Available

  • Nicox Clinical Site

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Nicox Clinical Site

    Rock Island, Illinois 61201
    United States

    Site Not Available

  • Nicox Clinical Site

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Nicox Clinical Site

    Bangor, Maine 04401
    United States

    Site Not Available

  • Nicox Clinical Site

    Boston, Massachusetts 02114
    United States

    Site Not Available

  • Nicox Clinical Site

    Lancaster, Massachusetts 01523
    United States

    Site Not Available

  • Nicox Clinical Site

    Grand Rapids, Michigan 49546
    United States

    Site Not Available

  • Nicox Clinical Site

    Chaska, Minnesota 55318
    United States

    Site Not Available

  • Nicox Clinical Site

    Kansas City, Missouri 64111
    United States

    Site Not Available

  • Nicox Clinical Site

    Saint Louis, Missouri 63128
    United States

    Site Not Available

  • Nicox Clinical Site

    Bronx, New York 10467
    United States

    Site Not Available

  • Nicox Clinical Site

    Clifton Park, New York 12065
    United States

    Site Not Available

  • Nicox Clinical Site

    Troy, New York 12180
    United States

    Site Not Available

  • Nicox Clinical Site

    Asheville, North Carolina 28803
    United States

    Site Not Available

  • Nicox Clinical Site

    Winston-Salem, North Carolina 27101
    United States

    Site Not Available

  • Nicox Clinical Site

    Fargo, North Dakota 58103
    United States

    Site Not Available

  • Nicox Clinical Site

    Cincinnati, Ohio 45242
    United States

    Site Not Available

  • Nicox Clinical Site

    Eugene, Oregon 97401
    United States

    Site Not Available

  • Nicox Clinical Site

    Cranberry Township, Pennsylvania 16066
    United States

    Site Not Available

  • Nicox Clinical Site

    Kingston, Pennsylvania 18704
    United States

    Site Not Available

  • Nicox Clinical Site

    Memphis, Tennessee 38119
    United States

    Site Not Available

  • Nicox Clinical Site

    Austin, Texas 78731
    United States

    Site Not Available

  • Nicox Clinical Site

    El Paso, Texas 79922
    United States

    Site Not Available

  • Nicox Clinical Site

    Houston, Texas 77025
    United States

    Site Not Available

  • Nicox Clinical Site

    Mission, Texas 78572
    United States

    Site Not Available

  • Nicox Clinical Site

    San Antonio, Texas 78238
    United States

    Site Not Available

  • Nicox Clinical Site

    Sugar Land, Texas 77479
    United States

    Site Not Available

  • Nicox Clinical Site

    Saint George, Utah 84790
    United States

    Site Not Available

  • Nicox Clinical Site

    Falls Church, Virginia 22042
    United States

    Site Not Available

  • Nicox Clinical Site

    Bellevue, Washington 98004
    United States

    Site Not Available

  • Nicox Clinical Site

    Seattle, Washington 98125
    United States

    Site Not Available

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