Fibrin Glue After ESD for High Risk Patients of Bleeding

Inclusion Criteria:

• ECOG performance status 0-1

• Patients scheduled to undergo ESD due to gastric tumor (dysplasia, early gastriccancer)

• Patients who are expected to have an iatrogenic ulcer size of 40mm or more afterendoscopic submucosal dissection, or are taking aspirin, antiplatelet drugs, oranticoagulants

• Patients who show adequate patient compliance and have adequate geographic distancefor follow-up observation.

Exclusion Criteria:

• Patients with sensitivity to cow protein or its derived ingredients

• Patients who had previously undergone partial gastrectomy

• Patients with early gastric cancer at the site previously undergoing ESD

• Patients with clinically significant cardiopulmonary disease

• Patients with active hepatitis, liver disease that is not well controlled bytreatment, or severe liver disorder

• Patients with severe renal impairment

• Patients with severe bone marrow dysfunction

• Patients with severe blood clotting impairment (including hemophilia)

• Patients with serious neurological or mental illness (e.g. epilepsy or dementia)

• Patients with reported side effects of contrast media

• Pregnant and lactating women

• Patients who have not obtained the informed consent of the patient and guardian

• Patients who are inadequate for clinical trials as judged by the attending physician