PASSIvation of Vulnerable Plaque With AZD5718 in AcuTe Coronary syndromE

Inclusion Criteria:

• hospitalised for STEMI or non-STEMI, as defined by the 4th universal definition ofMI

• underwent coronary angiography during the index hospitalisation showing at least oneepicardial coronary artery with ≥50% stenosis and a 2nd epicardial coronary arterywith ≥20% stenosis on the coronary angiogram

• Body Mass Index (BMI) ≥18 to ≤40 kg/m2

• White Blood Cell count ≥ 7.0 X 103/uL during admission

Exclusion Criteria:

• Prior coronary artery bypass grafting (CABG)

• CABG planned within 12 months of admission

• Known history of drug or alcohol abuse within 5 years of screening

• History of QT prolongation associated with other medications that requireddiscontinuation of that medication

• Congenital long QT syndrome

• Systolic blood pressure persistently <90 mm Hg or HR<40 beats per minute at time ofenrolment

• ALT >2 x ULN, cirrhosis, recent hepatitis, or positive screening test for hepatitisB (hepatitis B surface antigen) or other viral hepatitis

• Uncontrolled Type 1 or Type 2 DM defined as HbA1c >10% or 74.9 mmol/mol (by IFCC)

• Any planned coronary revascularisation, valve surgery, or cardiac resynchronisationwithin 7 months after randomisation

• Any concomitant medications known to be associated with Torsades de Pointes orpotent inducers of cytochrome P450 3A4 (CYP3A4)

• Planned treatment with zileuton, leukotriene receptor antagonists (e.g.,montelukast) during trial

• Participated in another interventional clinical study with an investigationalpharmaceutical product during the last 3 months

• Known hypersensitivity to drugs with a similar chemical structure or class of studydrugs or any of the excipients of the product

• Known conditions that either increase the risk of performing the CT or make theprocedure technically impractical

• No severe asthma attack that require emergency treatment or hospitalisation in thepast 6 months

• Had severe course of COVID-19 (extracorporeal membrane oxygenation, mechanicallyventilated), and/or had a confirmed case of COVID-19 within 4 weeks of ScreeningVisit